Association between underweight and pulmonary function in 282,135 healthy adults: A cross-sectional study in Korean population
Association between underweight and pulmonary function in 282,135 healthy adults: A cross-sectional study in Korean population
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DOI：
10.1038/s41598-019-50488-3
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发表时间：
2019-10-04
影响因子：
4.6
通讯作者：
Yoon, Kyung Jae
中科院分区：
文献类型：
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作者：
Do, Jong Geol;Park, Chul-Hyun;Yoon, Kyung Jae
与肥胖相反，关于体重过轻与肺功能之间关系的研究仍然很少。因此，本研究的目的是在无明显肺部疾病的普通人群中调查体重过轻对肺功能的影响。研究纳入了2012年1月至2014年12月期间韩国的282135名回顾性队列研究对象。通过多变量调整分析，评估了体重指数（BMI）与肺功能之间的关系。体重过轻的个体占研究总人群（n = 282135）的5.5%，其中大多数（87.9%）为女性。与正常体重和肥胖者相比，体重过轻与肺功能下降有关。在调整年龄、性别、身高、吸烟状况、剧烈运动频率、糖尿病和高敏C反应蛋白（hsCRP）后，体重过轻组的第一秒用力呼气量（FEV1）、预计FEV1（%）、用力肺活量（FVC）、预计FVC（%）和呼气峰流量（PEF）均低于其他组（P < 0.001）。较低的BMI往往会降低肺功能参数，如FEV1（升）、预计FEV1（%）、FVC（升）、预计FVC（%）和PEF（升/秒）（趋势P值未完整，翻译至此）
In contrast to obesity, studies on the relationship between underweight and pulmonary function are still sparse. Thus, the objective of this study was to investigate the effect of being underweight on pulmonary function in a general population without apparent lung disease. A total of 282,135 retrospective cohort subjects between January 2012 and December 2014 in Korea were included. Using multivariate-adjusted analysis, the relationship between body mass index (BMI) and pulmonary function were assessed. Underweight individuals represented 5.5% of the total study population (n = 282,135), with most (87.9%) of them being females. Compare to normal weight and obese, underweight was associated with decreased pulmonary function. Forced expiratory volume in first second (FEV1), predicted FEV1 (%), forced vital capacity (FVC), predicted FVC (%), and peak expiratory flow (PEF) were lower in the underweight group than those in other groups after adjusting for age, sex, height, status of smoking, frequency of vigorous exercise, diabetes, and high-sensitivity C-reactive protein (hsCRP) (P < 0.001). Lower BMI tended to decrease pulmonary function parameters such as FEV1 (L), predicted FEV1 (%), FVC (L), predicted FVC (%), and PEF (L/sec) (P for trend