Hemodynamic and morphological vasculature response to a burn monitored using a combined dual-wavelength laser speckle and optical microangiography imaging system.
Hemodynamic and morphological vasculature response to a burn monitored using a combined dual-wavelength laser speckle and optical microangiography imaging system.
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DOI：
10.1364/boe.3.000455
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发表时间：
2012-03-01
影响因子：
3.4
通讯作者：
Wang R
中科院分区：
文献类型：
--
作者：
Qin J;Reif R;Zhi Z;Dziennis S;Wang R
多功能成像系统能够确定血流，血红蛋白浓度和血管形态特征的相对变化。该系统结合了两种非侵入性成像技术，双波长激光散斑对比成像（2-LSI）和光学微血管成像（OMAG）系统。2-LSI用于监测动态血流的变化以及氧合（HbO）、脱氧（Hb）和总血红蛋白（HbT）浓度的变化。OMAG系统用于获取功能血管网络的高分辨率图像。血管面积密度（VAD）用于量化血管网络形态，特别是毛细血管募集。该多功能系统用于评估小鼠耳廓在烧伤前后的血流灌注状况。据我们所知，这是第一种可以同时测量几种血液灌注参数变化的非侵入性、非接触式和多功能成像方式。
A multi-functional imaging system capable of determining relative changes in blood flow, hemoglobin concentration, and morphological features of the blood vasculature is demonstrated. The system combines two non-invasive imaging techniques, a dual-wavelength laser speckle contrast imaging (2-LSI) and an optical microangiography (OMAG) system. 2-LSI is used to monitor the changes in the dynamic blood flow and the changes in the concentration of oxygenated (HbO), deoxygenated (Hb) and total hemoglobin (HbT). The OMAG system is used to acquire high resolution images of the functional blood vessel network. The vessel area density (VAD) is used to quantify the blood vessel network morphology, specifically the capillary recruitment. The proposed multi-functional system is employed to assess the blood perfusion status from a mouse pinna before and immediately after a burn injury. To our knowledge, this is the first non-invasive, non-contact and multifunctional imaging modality that can simultaneously measure variations of several blood perfusion parameters.