Tau Structures.
Tau Structures.
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DOI：
10.3389/fnagi.2016.00262
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发表时间：
2016
影响因子：
4.8
通讯作者：
Hernández F
中科院分区：
文献类型：
--
作者：
Avila J;Jiménez JS;Sayas CL;Bolós M;Zabala JC;Rivas G;Hernández F
Tau是一种微管相关蛋白，在轴突稳定、神经元发育和神经元极性中起重要作用。在这篇综述中，我们专注于初级，二级，三级和四级tau结构。我们描述了tau蛋白的结构，从其特定的残基，直到其在二聚体，低聚物和较大的聚合物在生理和病理情况下的构象。
Tau is a microtubule-associated protein that plays an important role in axonal stabilization, neuronal development, and neuronal polarity. In this review, we focus on the primary, secondary, tertiary, and quaternary tau structures. We describe the structure of tau from its specific residues until its conformation in dimers, oligomers, and larger polymers in physiological and pathological situations.