EXAMINATION OF IMMUNE PARAMETERS AND HOST-RESISTANCE MECHANISMS IN B6C3F1 MICE FOLLOWING ADULT EXPOSURE TO 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN
EXAMINATION OF IMMUNE PARAMETERS AND HOST-RESISTANCE MECHANISMS IN B6C3F1 MICE FOLLOWING ADULT EXPOSURE TO 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN
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DOI：
10.1080/15287399009531449
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发表时间：
1990-01-01
期刊：
影响因子：
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通讯作者：
DEAN, JH
中科院分区：
文献类型：
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作者：
HOUSE, RV;LAUER, LD;DEAN, JH
对成年雌性B6 C3 F1小鼠单次ip给予0、0.1、1.0或10.0 μ g/kg的2，3，7，8-四氯二苯并-对-二恶英（TCDD），并在7-10天后检查免疫功能和宿主抗性。暴露于TCDD导致IgM和IgG抗体形成细胞的诱导出现显著的剂量相关性下降。T依赖性和T非依赖性抗原均观察到这种抑制。10 μ g/kg剂量的TCDD显示抑制病毒血凝素抗体的产生。相比之下，TCDD暴露对自然杀伤细胞功能，干扰素的产生或巨噬细胞功能的各种参数没有显着影响。对宿主耐药性的评估显示，对流感病毒致命感染的易感性显著增加，但对单核细胞增生李斯特菌感染的易感性无显著改变。
Adult female B6C3F1 mice were given a single ip dose of 0, 0.1, 1.0, or 10.0 .mu.g/kg 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and examined for immune function and host resistance 7-10 d later. Exposure to TCDD resulted in a significant dose-related decrease in induction of both IgM and IgG antibody-forming cells. This suppression was noted for both T-dependent and T-independent antigens. TCDD at a dosage of 10 .mu.g/kg was shown to suppress production of antibody to viral hemagglutinin. In contrast, TCDD exposure had no significant effect on natural killer cell function, production of interferon, or various parameters of macrophage function. Assessment of host resistance revealed a significant increase in susceptibility to fatal infection with influenza virus, but no significant alteration in susceptibility to infection with the bacterium Listeria monocytogenes.