Prevalence of gastrointestinal symptoms in young and middle-aged diabetic patients
Prevalence of gastrointestinal symptoms in young and middle-aged diabetic patients
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DOI：
10.1080/003655299750024706
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发表时间：
1999-12-01
影响因子：
1.9
通讯作者：
Lithner, F
中科院分区：
文献类型：
--
作者：
Spångéus, A;El-Salhy, M;Lithner, F
背景：糖尿病患者中有胃肠道疾病的报道。本研究旨在评估瑞典于默奥县门诊糖尿病患者胃肠道症状的发生频率。方法：将居住在Umea县（人口136,000）的24-59岁糖尿病患者纳入研究（n = 489），性别200；以及年龄匹配的健康对照。将调查问卷邮寄给患者和对照组，并在5个月后发送提醒。问卷包含28个问题，涉及前一年的胃肠道症状、排便习惯和用药情况。结果：59%的患者和53%的对照组有反应。患者报告的胃肠道症状总数（1.25 +/- 0.10；平均+/-标准差）显著高于对照组（0.50 +/- 0.08）。这种增加在1型（1.12 +/- 0.11）和2型（1.52 +/- 0.25）糖尿病患者中均可见。女性糖尿病患者报告的症状明显多于男性患者（分别为1.59 +/- 0.17和0.81 +/- 0.12）。神经病变患者的症状明显多于其他患者。症状频率与肾病或视网膜病变、糖尿病病程、体重指数、糖化血红蛋白或胰岛素剂量无关。患者胃灼热、便秘和夜间排便的频率明显高于对照组。此外，排便不完全的感觉、排便时需要用力和急迫感在患者中更为常见。结论：糖尿病患者胃肠道症状多于非糖尿病人群。这些症状与死亡持续时间、代谢控制或除神经病变外的任何其他并发症无关。胃灼热和便秘是糖尿病患者比非糖尿病人群更常见的症状。
Background: Gastrointestinal disorders have been reported in patients with diabetes mellitus. The present investigation was carried out to evaluate the frequency of gastrointestinal symptoms in out-clinic diabetic patients in the county of Umea, Sweden. Methods: Diabetic patients aged 24-59 years residing in Umea County (population, 136,000) were included in the study (n = 489), as were 200 sex; and age-matched healthy controls. A questionnaire was mailed to the patients and controls, and a reminder was sent 5 months later. The questionnaire contained 28 questions concerning gastrointestinal symptoms, bowel habits, and medication during the preceding year. Results: Fifty-nine per cent of the patients and 53% of the controls responded. The total number of reported gastrointestinal symptoms was significantly greater in patients (1.25 +/- 0.10; mean +/- standard deviation) than in control subjects (0.50 +/- 0.08). This increase was seen in both type-1 (1.12 +/- 0.11) and type-2 (1.52 +/- 0.25) diabetic patients. Female diabetic patients reported significantly more symptoms than did male patients (1.59 +/- 0.17 and 0.81 +/- 0.12, respectively). Patients with neuropathy had significantly more symptoms than the other patients. Symptom frequency was nor correlated with nephropathy or retinopathy or with the duration of diabetes, body mass index, glycosylated haemoglobin, or insulin dose. Heartburn, constipation, and nocturnal urge to defecate were significantly more frequent in patients than in controls. Furthermore, a feeling of incomplete defecation, a need to strain at defecation, and urgency were significantly more common in patients. Conclusion: Diabetic patients had more gastrointestinal symptoms than non-diabetic population. These symptoms did not correlate with duration of die disease, metabolic control, or any other complication except neuropathy. Heartburn and constipation were among the symptoms that occurred more frequently in diabetic patients than in the non-diabetic population.