Patterns of cerebral atrophy in dementia with Lewy bodies using voxel-based morphometry
Patterns of cerebral atrophy in dementia with Lewy bodies using voxel-based morphometry
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DOI：
10.1006/nimg.2002.1197
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发表时间：
2002-10-01
期刊：
影响因子：
5.7
通讯作者：
O'Brien, JT
中科院分区：
文献类型：
--
作者：
Burton, EJ;Karas, G;O'Brien, JT
先前基于感兴趣区分析的横断面MRI研究表明，大脑萎缩加剧是路易体痴呆(DLB)和阿尔茨海默病(AD)的一个特征。在基于感兴趣区的研究中，与AD相比，DLB患者的海马体和颞叶结构相对保存得更好。最近，基于体素的形态测量(VBM)等图像处理技术已经发展起来，为研究脑萎缩的模式提供了一种无偏见的、视觉上信息丰富的综合手段。我们报告了第一项使用基于体素的方法来评估与对照组和AD患者相比的DLB患者的脑萎缩模式的研究。与对照组相比，DLB患者双侧颞叶、额叶和岛叶皮质的局部灰质体积减少。痴呆组的比较显示，与AD相比，DLB中保留了内侧颞叶、海马体和杏仁核。与DLB相比，AD患者丘脑也有显著的灰质丢失。(C)2002年埃尔塞维尔科学公司(美国)。
Previous cross-sectional MRI studies based on region-of-interest analyses have shown that increased cerebral atrophy is a feature of both Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). Relative preservation of the hippocampus and temporal lobe structures in DLB compared to AD has been reported in region-of-interest-based studies. Recently, image processing techniques such as voxel-based morphometry (VBM) have been developed to provide an unbiased, visually informative, and comprehensive means of studying patterns of cerebral atrophy. We report the first study to use the voxel-based approach to assess patterns of cerebral atrophy in DLB compared to control subjects and AD. Regional gray matter volume loss was observed bilaterally in the temporal and frontal lobes and insular cortex of patients with DLB compared to control subjects. Comparison of dementia groups showed preservation of the medial temporal lobe, hippocampus, and amygdala in DLB relative to AD. Significant gray matter loss was also observed in the thalamus of AD patients compared to DLB. (C) 2002 Elsevier Science (USA).