Effects of exercise-induced weight loss on low density lipoprotein subfractions in healthy men.

Effects of exercise-induced weight loss on low density lipoprotein subfractions in healthy men.
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运动引起的减肥对健康男性低密度脂蛋白亚组分的影响。

DOI:
10.1161/01.atv.9.5.623
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发表时间:
1989
期刊:
Arteriosclerosis (Dallas, Tex.)
影响因子:
--
通讯作者:
Wood,PD
Wood,PD
中科院分区:
--
文献类型:
--
作者:
Williams,PT;Krauss,RM;Vranizan,KM;Albers,JJ;Terry,RB;Wood,PD

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低密度脂蛋白(LDL)峰值浮动率(Sf)和血清中Sf 0至7 LDL质量浓度的一年变化(小LDL),Sf 7至12的LDL(大LDL),Sf 12至20的中密度脂蛋白(IDL),和极低密度脂蛋白(VLDL)的Sf 20至400之间的男性进行了比较,随机分配到一个为期1年的运动计划(N = 48)或久坐控制条件(N = 31)。锻炼者之间的跑步距离差异很大(平均值+/- SD:12.7 +/- 8.9 km/周)。运动组和对照组的任何低密度至极低密度脂蛋白测量值的平均变化均无显著差异。然而,在运动组内:1)长跑与小LDL质量浓度的变化呈负相关; 2)体重减轻和减少上身肥胖与小LDL、IDL和VLDL质量的变化呈正相关,与LDL峰值浮动率的变化呈负相关。偏相关分析表明,体重减轻可能主要通过与高密度脂蛋白2或小VLDL(Sf 20至60)相关的代谢过程影响LDL质量分布。小LDL浓度的降低和LDL峰值浮动率的增加表明,运动引起的体重减轻可能有效地降低遗传上易患高危脂蛋白的人患冠心病的风险。
One-year changes in low density lipoprotein (LDL) peak flotation (Sf) rate and serum mass concentrations of LDL of Sf 0 to 7 (small LDL), LDL of Sf 7 to 12 (large LDL), intermediate density lipoprotein (IDL) of Sf 12 to 20, and very low density lipoprotein (VLDL) of Sf 20 to 400 were compared between men assigned at random to a 1-year exercise program (N = 48) or to a sedentary control condition (N = 31). Distance run among exercisers varied substantially (mean +/- SD: 12.7 +/- 8.9 km/week). Mean changes were not significantly different between the exercise and control groups for any of the low to very low density lipoprotein measurements. However, within the exercise group: 1) distance run correlated negatively with changes in the mass concentrations of small LDL; and 2) weight loss and reduced upper body obesity correlated positively with changes in small LDL, IDL, and VLDL mass and negatively with change in LDL peak flotation rate. Analyses with partial correlations suggest that weight loss may primarily affect LDL mass distributions through metabolic processes associated with high density lipoprotein2 or small VLDL (Sf 20 to 60). The decrease in small LDL concentrations and the increase in LDL peak flotation rate suggest that exercise-induced weight loss may be effective in reducing coronary heart disease risk in persons genetically predisposed to a high-risk lipoprotein profile.
正常、肥胖和动脉粥样硬化受试者的血清脂质和脂肪耐受性研究
DOI: 10.1161/01.cir.10.5.742
发表时间: 1954
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影响因子: 37.8
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DOI: --
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影响因子: 5.3
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