Body mass index and hepatic lipase gene (LIPC) polymorphism jointly influence postheparin plasma hepatic lipase activity.
Body mass index and hepatic lipase gene (LIPC) polymorphism jointly influence postheparin plasma hepatic lipase activity.
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发表时间：
1998-05
影响因子：
6.5
通讯作者：
Liangcai Nie;Jinping Wang;Luther T. Clark;Aylmer Tang;G. L. Vega;Scott M. Grundy;J. Cohen
中科院分区：
文献类型：
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作者：
Liangcai Nie;Jinping Wang;Luther T. Clark;Aylmer Tang;G. L. Vega;Scott M. Grundy;J. Cohen
肝脂酶基因（LIPC）-514多态性与肝脂酶活性降低相关。在本研究中，在118名白色男性和51名非洲裔美国男性中检查了体重指数（BMI）、-514多态性和肝脂肪酶活性之间的相互作用。两个人群中BMI与肝脂酶活性均呈显著正相关。在肝脂肪酶活性具有遗传差异的男性中，BMI相似，表明高肝脂肪酶活性不会导致BMI增加。因此，数据表明，高BMI导致肝脂肪酶活性增加。BMI和-514多态性对肝脂肪酶活性的作用似乎是相加的和独立的，而不是协同的。这一发现表明，肝脂肪酶活性是一个多因素的性状，部分取决于LIPC基因内的多态性以及影响BMI的因素。
The -514 polymorphism in the hepatic lipase gene (LIPC) is associated with decreased hepatic lipase activity. In the present study, the interaction between body mass index (BMI), the -514 polymorphism, and hepatic lipase activity was examined in 118 white men and in 51 African American men. BMI was significantly positively correlated with hepatic lipase activity in both populations. BMI was similar in men with genetic differences in hepatic lipase activity, indicating that high hepatic lipase activity did not cause increased BMI. The data therefore suggest that high BMI leads to increased hepatic lipase activity. The actions of BMI and the -514 polymorphism on hepatic lipase activity appear to be additive and independent, rather than synergistic. This finding indicates that hepatic lipase activity is a multifactorial trait, determined in part by polymorphism within the LIPC gene as well as by factors that influence BMI.