Development and utilization of non-coding RNA-small molecule interactions
Development and utilization of non-coding RNA-small molecule interactions
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DOI：
10.1039/c1ob06324c
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发表时间：
2011-01-01
影响因子：
3.2
通讯作者：
Young, Douglas D.
中科院分区：
文献类型：
--
作者：
Georgianna, Wesleigh E.;Young, Douglas D.
RNA作为遗传信息的载体在细胞生物学中起着至关重要的作用。然而，除了这种被动作用之外，RNA已被证明以不翻译成蛋白质的形式调节各种细胞过程。非编码RNA（ncRNA）已被证明是重要的基因调控，其异常活动已与几种疾病状态。因此，ncRNA代表了小分子调控的新靶点，最近，在阐明ncRNA的小分子调控因子方面取得了重大进展。在此，我们提供了一个概述的miRNA，siRNA，RNA适体，核糖开关和核酶，在最近的研究结果的背景下，这些小分子的外源性调控。这些小分子工具的开发在分子治疗学的发展中具有深远的应用。
RNA plays a crucial role in cellular biology as a carrier of genetic information. However, beyond this passive role, RNA has been shown to regulate various cellular processes in a form that is not translated into protein. Non-coding RNA (ncRNA) has been shown to be important in gene regulation, and its aberrant activity has been associated with several disease states. As such, ncRNAs represent a novel target for small molecule regulation and recently, significant advances have been made towards elucidating small molecule regulators of ncRNAs. Herein, we provide an overview of miRNA, siRNA, RNA aptamers, riboswitches, and ribozymes, within the context of recent findings regarding the exogenous regulation of these ncRNAs by small molecules. The development of these small molecule tools has far-reaching applications in the advancement of molecular therapeutics.