Laser Scanning Tomography of Optic Discs of the Normal Japanese Population in a Population-based Setting
Laser Scanning Tomography of Optic Discs of the Normal Japanese Population in a Population-based Setting
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DOI：
10.1016/j.ophtha.2008.09.013
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发表时间：
2009-02-01
期刊：
影响因子：
13.7
通讯作者：
Yamamoto, Tetsuya
中科院分区：
文献类型：
--
作者：
Abe, Haruki;Shirakashi, Motohiro;Yamamoto, Tetsuya
目的：利用Heidelberg视网膜断层扫描（HRT） II评估日本正常人视盘特征。设计：横断面研究。参与者：参与日本人群眼科研究Tajimi Study的3021名40岁及以上受试者6042只眼睛中，2036名正常受试者3576只眼睛，HRT II图像质量良好。方法：采用HRT II获取视盘参数，并采用简单回归和多元回归分析评估性别、年龄、身高、体重、血压、眼灌注压、屈光度、眼内压（IOP）、角膜中央厚度（CCI）、视盘大小与HRT参数的关系。主要观察指标：HRT参数，包括椎间盘面积、杯面积、杯缘面积、杯盘面积比、杯体积、杯缘体积、平均杯深、最大杯深、高度变化轮廓、杯形测量、平均视网膜神经纤维层（RNFL）厚度、RNFL横截面积，以及潜在混杂因素与HRT参数的粗相关性和偏相关性。结果：椎间盘面积、杯盘面积比和边缘面积平均分别为2.06 +/- 0.41 mm(2)（平均+/-标准差）、0.23 +/- 0.13和1.55 +/- 0.29 mm(2)。所有HRT参数在右眼和左眼之间呈强或中度相关(Pearson相关系数= 0.45-0.83，P
Objective: To evaluate the optic disc characteristics using the Heidelberg retina tomograph (HRT) II in a large sample of normal Japanese subjects.Design: Cross-sectional study.Participants: A total of 3576 eyes of 2036 normal subjects, with good-quality HRT II images, of 6042 eyes of 3021 subjects aged 40 years or more who participated in the Tajimi Study, a population-based eye study in Japan.Methods: Optic disc parameters were obtained using HRT II, and the association of gender, age, height, weight, blood pressure, ocular perfusion pressure, refraction, intraocular pressure (IOP), central corneal thickness (CCI), and disc size on HRT parameters was assessed using simple and multiple regression analyses.Main Outcome Measures: HRT parameters, including disc area, cup area, rim area, cup-to-disc area ratio, cup volume, rim volume, mean cup depth, maximum cup depth, height variation contour, cup shape measure, mean retinal nerve fiber layer (RNFL) thickness, and RNFL cross-sectional area, and the crude and partial correlations of the potential confounders with the HRT parameters.Results: Disc area, cup-to-disc area ratio, and rim area averaged 2.06 +/- 0.41 mm(2) (mean +/- standard deviation), 0.23 +/- 0.13, and 1.55 +/- 0.29 mm(2), respectively. All HRT parameters were strongly or moderately correlated between right and left eyes (Pearson's correlation coefficients = 0.45-0.83, P