Dielectric Coatings for Resistive Pulse Sensing Using Solid-State Pores
Dielectric Coatings for Resistive Pulse Sensing Using Solid-State Pores
复制标题
使用固态孔进行电阻脉冲传感的介电涂层
DOI：
10.1021/acsami.0c22548
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发表时间：
2021
影响因子：
9.5
通讯作者：
Taniguchi Masateru
中科院分区：
文献类型：
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作者：
Hayashida Tomoki;Tsutsui Makusu;Murayama Sanae;Nakada Tomoko;Taniguchi Masateru
本研究报告了系统表征介质涂层对固体孔隙中单个颗粒的捕获-迁移动力学的有效性。我们用SiO2， HfO2, Al2O3， TiO2或ZnO覆盖sinx膜的表面，这使我们能够改变孔壁的ζ电位，反映这些涂层材料的等电点。带负电荷的聚苯乙烯珠的电阻脉冲测量表明，在氧化物表面更负的电势下，粒子的电泳捕获更容易，通道中的易位运动更慢。这些发现为孔壁面的工程设计提供了指导，以优化颗粒和分子的有效传感的易位动力学。
The present study reports on the systematic characterization of the effectiveness of dielectric coating to tailor capture-to-translocation dynamics of single particles in solid-state pores. We covered the surface of SiNxmembranes with SiO2, HfO2, Al2O3, TiO2, or ZnO, which allowed us to change the ζ-potential at the pore wall, reflecting the isoelectric points of these coating materials. Resistive pulse measurements of negatively charged polystyrene beads elucidated more facile electrophoretic capture of the particles and slower translocation motions in the channel under more negative electric potential at the oxide surface. These findings provide a guide to engineer pore wall surface for optimizing the translocation dynamics for efficient sensing of particles and molecules.