Effects of the Ordering of Natural Selection and Population Regulation Mechanisms on Wright-Fisher Models.
Effects of the Ordering of Natural Selection and Population Regulation Mechanisms on Wright-Fisher Models.
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DOI：
10.1534/g3.117.041038
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发表时间：
2017-07-05
期刊：
影响因子：
--
通讯作者：
Yu F
中科院分区：
文献类型：
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作者：
He Z;Beaumont M;Yu F
我们探讨了不同的自然选择机制对单基因座和双基因座系统种群进化的影响。我们将赖特-费希尔模型中生存力和繁殖力选择的效果与乘性适应度假设下的选择进行比较。我们表明，这两种自然选择模式对应于赖特-费舍尔模型中种群调节和自然选择过程的不同顺序。我们发现，在赖特-费舍尔模型下，这两种不同的排序可以影响随着遗传重组而进化的单倍型频率的轨迹分布。然而，只有当总体处于显着的连锁不平衡状态时，轨迹分布的差异才会明显。我们发现，随着连锁不平衡的减弱，两种不同模型的轨迹很快变得难以区分。我们根据生存力和繁殖力选择的生物学例子讨论了这些发现的重要性，并推测当基因迁移等因素维持一定程度的连锁不平衡时，这种影响可能是显着的。
We explore the effect of different mechanisms of natural selection on the evolution of populations for one- and two-locus systems. We compare the effect of viability and fecundity selection in the context of the Wright-Fisher model with selection under the assumption of multiplicative fitness. We show that these two modes of natural selection correspond to different orderings of the processes of population regulation and natural selection in the Wright-Fisher model. We find that under the Wright-Fisher model these two different orderings can affect the distribution of trajectories of haplotype frequencies evolving with genetic recombination. However, the difference in the distribution of trajectories is only appreciable when the population is in significant linkage disequilibrium. We find that as linkage disequilibrium decays the trajectories for the two different models rapidly become indistinguishable. We discuss the significance of these findings in terms of biological examples of viability and fecundity selection, and speculate that the effect may be significant when factors such as gene migration maintain a degree of linkage disequilibrium.