Neuroprotective effects of pramipexole in young and aged MPTP-treated mice
Neuroprotective effects of pramipexole in young and aged MPTP-treated mice
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DOI：
10.1016/s0006-8993(01)02466-0
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发表时间：
2001-06-29
期刊：
影响因子：
2.9
通讯作者：
Schneider, JS
中科院分区：
文献类型：
--
作者：
Anderson, DW;Neavin, T;Schneider, JS
本研究检查了普拉克索（PPX）（一种选择性多巴胺（DA）D-3/D-2激动剂）对1-甲基-4-苯基-1，2，3，6-四氢吡啶（MPTP）诱导的年轻（8周龄）和老年（12月龄）小鼠黑质纹状体多巴胺系统损伤的影响。共同管理PPX和MPTP的年轻或老年小鼠，随后2或14天的额外PPX治疗，显着衰减MPTP诱导的纹状体DA损失。普拉克索给药还显著减弱了幼龄和老龄动物黑质丘脑部（SNc）内酪氨酸羟化酶免疫反应性神经元（TH-IR）的丢失。在Niss 1染色切片和定量逆行标记的荧光金阳性SNc神经元中证实了PPX给药对多巴胺能细胞存活的影响。PPX对纹状体DA水平和SNc DA神经元存活的保护作用在年轻和老年动物中是相似的，尽管这些作用的幅度在老年动物中显著较小。这些发现支持帕金森病患者早期开始PPX治疗。(C)2001 Elsevier Science B. V.保留所有权利。
This study examined the effect of pramipexole (PPX), a selective dopamine (DA) D-3/D-2 agonist, on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced damage to the nigrostriatal dopamine system in young (8-week-old) and aged (12-month-old) mice. Co-administration of PPX and MPTP to young or aged mice, followed by 2 or 14 days of additional PPX treatment, significantly attenuated MPTP-induced striatal DA loss. Pramipexole treatment also significantly attenuated the loss of tyrosine hydroxylase immunoreactive neurons (TH-IR) within the substantia nigra pars compacta (SNc) in both young and aged animals. Effects of PPX administration on dopaminergic cell survival were confirmed in Niss1-stained sections and by quantitation of retrogradely labeled Fluorogold-positive SNc neurons. Protective effects of PPX on striatal DA levels and SNc DA neuron survival were similar in young and aged animals, although the magnitude of these effects was significantly less in aged animals. These findings support the early initiation of PPX therapy in Parkinson's disease patients. (C) 2001 Elsevier Science B.V. All rights reserved.