Influence of coronary artery diameter on eNOS protein content
Influence of coronary artery diameter on eNOS protein content
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DOI：
10.1152/ajpheart.00792.2002
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发表时间：
2003-04-01
影响因子：
4.8
通讯作者：
Price, EM
中科院分区：
文献类型：
--
作者：
Laughlin, MH;Turk, JR;Price, EM
本研究的目的是验证冠状动脉树内皮型一氧化氮合酶（eNOS）蛋白含量（eNOS蛋白/g总动脉蛋白）随动脉直径减小而增加的假设。采用免疫印迹法测定猪冠状动脉中eNOS蛋白的含量。从每个心脏中分离出6种动脉：大动脉[301- 2500 μ m内径（ID）]、小动脉（201- 300 μ m内径）、阻力动脉（151- 200 μ m内径）、大动脉（101- 150 μ m内径）、中间小动脉（51- 100 μ m内径）和小动脉(
The purpose of this study was to test the hypothesis that the content of endothelial nitric oxide synthase (eNOS) protein (eNOS protein/g total artery protein) increases with decreasing artery diameter in the coronary arterial tree. Content of eNOS protein was determined in porcine coronary arteries with immunoblot analysis. Arteries were isolated in six size categories from each heart: large arteries [301- to 2,500-mum internal diameter (ID)], small arteries (201- to 300-mum ID), resistance arteries (151- to 200-mum ID), large arterioles (101- to 150-mum ID), intermediate arterioles (51- to 100-mum ID), and small arterioles(