Age-related sarcopenia in humans is associated with reduced synthetic rates of specific muscle proteins
Age-related sarcopenia in humans is associated with reduced synthetic rates of specific muscle proteins
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DOI：
10.1093/jn/128.2.351s
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发表时间：
1998-02-01
影响因子：
4.2
通讯作者：
Nair, KS
中科院分区：
文献类型：
--
作者：
Proctor, DN;Balagopal, P;Nair, KS
衰老引起的肌肉减少症并不能完全用与年龄相关的体力活动减少来解释，进行性神经肌肉变化和合成代谢激素水平降低被认为是导致肌肉减少症的发病机制。肌肉质量的下降表明肌肉蛋白质含量的下降。最近的研究表明，混合肌肉蛋白、肌球蛋白重链和线粒体蛋白的合成率与年龄相关。肌球蛋白重链和线粒体蛋白合成率的降低分别与年龄相关的肌肉力量和有氧运动耐量下降相关。这些变化早在 50 岁就已有报道，与胰岛素样生长因子 (IGF)-I、睾酮的下降有关。和硫酸脱氢表雄酮（DHEA）。因此，重塑这些重要肌肉蛋白的能力下降可能在老年时出现肌肉萎缩、代谢异常和身体功能受损的过程中发挥作用。
Sarcopenia of aging is not explained entirely on the basis of age-associated reduced physical activity, Progressive neuromuscular changes and diminishing anabolic hormone levels are thought to contribute to the pathogenesis of sarcopenia. Decline in muscle mass indicates a decline in muscle protein content, Recent studies demonstrated an age-related decline in synthesis rate of mixed muscle proteins, myosin heavy chain and mitochondrial protein, Reductions in myosin heavy chain and mitochondrial protein synthesis rates have been correlated with age-associated decrements in muscle strength and aerobic exercise tolerance, respectively, These changes ha le been reported as early as 50 y of age and are related to the decline in insulin-like growth factor (IGF)-I, testosterone and dehydroepiandrosterone (DHEA)-sulfate. The declining ability to remodel these important muscle proteins may therefore play a role in the development of muscle wasting, metabolic abnormalities and impaired physical functioning seen in old age.