Deliveries of babies with normal health derived from oocytes with smooth endoplasmic reticulum clusters
Deliveries of babies with normal health derived from oocytes with smooth endoplasmic reticulum clusters
复制标题
DOI：
10.1007/s10815-014-0323-z
复制
发表时间：
2014-11-01
影响因子：
3.1
通讯作者：
Kyono, Koichi
中科院分区：
文献类型：
--
作者：
Hattori, Hiromitsu;Nakamura, Yusuke;Kyono, Koichi
To examine the impact on development of derived embryos from smooth endoplasmic reticulum clusters (SERC) in human metaphase II (MII) oocytes.Retrospective analysis at Kyono ART Clinic. Comparison of embryological development, pregnancy, live birth and fetal malformation between oocytes with SERC (the SERC(+) group) and those without (the SERC(-) group) in 2,158 patients (3,758 cycles) after ICSI.Fertilization and implantation rate were significantly lower in SERC(+) MII oocytes than in SERC(-) MII oocytes. After the transfer of fresh and vitrified embryos derived from SERC(+) oocytes, 14 pregnancies resulted in 14 healthy babies, including 2 from fresh embryo transfer (ET) and 12 from vitrified-warmed ET, with no malformations.The presence of SERC in MII oocytes was associated with significantly lower fertilization rates and implantation rates than seen in SERC(-) MII oocytes within SERC (+) cycles. However, SERC had no impact on post-implantation development as well as neonatal outcome.
