Test-Retest Variability of Reading Performance Metrics Using MNREAD in Patients with Age-Related Macular Degeneration
Test-Retest Variability of Reading Performance Metrics Using MNREAD in Patients with Age-Related Macular Degeneration
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DOI：
10.1167/iovs.10-6601
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发表时间：
2011-05-01
影响因子：
4.4
通讯作者：
Tufail, Adnan
中科院分区：
文献类型：
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作者：
Patel, Praveen J.;Chen, Fred K.;Tufail, Adnan
目的.目的探讨稳定期老年性黄斑变性（AMD）患者阅读能力的MNREAD量表重测变异性。在这项前瞻性研究中，在两次访视时测量了124例AMD患者的124只未治疗眼睛的阅读能力，这些患者参加了一项正在进行的使用标准化MNREAD方案的临床试验。只有在两次访视时都能在40 cm处进行阅读测试的稳定型AMD患者才被纳入分析。采用不同的评分规则来计算临界打印尺寸和最大阅读速度。对59例平均（SD）年龄为78（7.6）岁且符合研究标准的患者的数据进行了分析，两次测量之间的平均（SD）间隔为43（6）天。阅读敏锐度的95%重复性系数（CR）为0.30 logMAR。临界打印尺寸和最大阅读速度的CR取决于所应用的分析方法。这是一份关于稳定型AMD患者阅读表现指标的会话间重测变异性估计的报告。这些结果有助于确定AMD临床试验的终点，并有助于区分临床实践中的临床变化与测量变异性。（Invest Ophthalmol维斯科学。2011; 52：3854-3859）DOI：10.1167/iovs.10-6601
PURPOSE. To determine the test-retest variability of reading ability using the MNREAD charts in patients with stable age-related macular degeneration (AMD).METHODS. In this prospective study, reading ability was measured at two visits in 124 nontreated eyes of 124 patients with AMD, who were enrolled in an ongoing clinical trial using a standardized MNREAD protocol. Only patients with stable AMD who could perform the reading test at 40 cm at both visits were included in the analysis. Different scoring rules were applied to calculate critical print size and maximum reading speed.RESULTS. Data from the 59 patients with a mean (SD) age of 78 (7.6) years who met the study criteria were analyzed at a mean (SD) interval of 43 (6) days between measurements. The 95% coefficient of repeatability (CR) was 0.30 logMAR for reading acuity. The CR for critical print size and maximum reading speed varied depending on the analysis method applied.CONCLUSIONS. This is a report of estimates of the intersession test-retest variability of reading performance metrics in patients with stable AMD. The results are helpful both in defining end points in clinical trials for AMD and in distinguishing clinical change from measurement variability in clinical practice. (Invest Ophthalmol Vis Sci. 2011; 52: 3854-3859) DOI: 10.1167/iovs.10-6601