Microbiological aspects of Helicobacter pylori
Microbiological aspects of Helicobacter pylori
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幽门螺杆菌的微生物学方面
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
E. Koster
中科院分区：
文献类型：
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作者：
E. Koster
背景：自从十年前首次分离到幽门螺杆菌以来，人们对这种细菌的认识以及对胃生理和病理生理学的理解都有了很大的进步。目的：综述幽门螺杆菌的研究现状。结论：幽门螺杆菌特别适应其在胃粘液和胃上皮细胞中的生态位。细菌(酶、氨、毒素)和宿主因素是造成显著组织损伤的原因。细菌的培养可以进行耐药性测试，这对治疗至关重要，并可以确定毒力因素，这可能成为选择消化性溃疡疾病和胃癌一级预防患者的重要因素。
Background: Since the first isolation of Helicobacter pylori a decade ago, knowledge of this bacterium and understanding of gastric physiology and pathophysiology has advanced rapidly. Aim: To review the present state of knowledge of H. pylori. Conclusions: H. pylori is especially adapted to its ecological niche in the gastric mucus and on gastric epithelial cells. Bacterial (enzymes, ammonia, toxin) and host factors are responsible for marked tissue damage. Culture of the bacteria allows resistance testing, which is of critical importance for treatment, and determination of virulence factors, which may become important in selecting patients for primary prevention of peptic ulcer disease and gastric cancer.