Rotating shift work and the metabolic syndrome: a prospective study
Rotating shift work and the metabolic syndrome: a prospective study
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DOI：
10.1093/ije/dyn360
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发表时间：
2009-06-01
影响因子：
7.7
通讯作者：
Braeckman, L.
中科院分区：
文献类型：
--
作者：
De Bacquer, D.;Van Risseghem, M.;Braeckman, L.
背景
多项研究已证实轮班工作者心血管疾病风险升高。为了进一步探究这种关系，我们旨在评估轮班工作与代谢综合征（MetS）发病率之间的关联。
方法
在这项基于人群的前瞻性研究中，对来自比利时几家大公司的1529名员工进行了中位观察期为6.6年的随访，观察代谢综合征及其各个组成部分的发病情况。
结果
在基线水平，309名男性（20.2%）为轮班工作者。这些轮班工作者的代谢综合征发病率（每1000人年60.6例）与日班工作者（每1000人年37.2例）相比有所增加，优势比（95%置信区间）为1.77（1.34 - 2.32）。对潜在生活方式和工作相关混杂因素进行多变量调整仅对关联强度有轻微影响。代谢综合征的发病风险随着轮班工作年限的累积而独立逐渐增加。轮班工作不仅对作为一组病症的代谢综合征有影响，对其各个单独的组成部分也有影响。
结论
因此，前瞻性证据表明，轮班工作在6年期间会增加患代谢综合征的风险。
Background Several studies have documented on the elevated cardiovascular risk among shift workers. In order to further explore this relation, we aimed at assessing the association between rotating shift work and the incidence of the metabolic syndrome (MetS).Methods In this population-based prospective study, 1529 employees from several large Belgian companies were followed for a median observation period of 6.6 years with respect to the onset of the MetS and its separate components.Results At baseline, 309 men (20.2%) were rotating shift workers. The MetS incidence rate in these shift workers (60.6 per 1000 person-years) was increased in comparison with day workers (37.2 per 1000 person-years) with an odds ratio (95% CI) of 1.77 (1.34-2.32). Multivariate adjustment for potential lifestyle and work-related confounders did only marginally affect the strength of the association. The risk for the development of MetS gradually increased independently with accumulated years of shift work. Rotating shift work not only had an impact on MetS as a cluster of conditions but on each of its individual components as well.Conclusions Hence, prospective evidence was found that rotating shift work increases the risk for developing the MetS over a period of 6 years.