Effect of brain shift on the creation of functional atlases for deep brain stimulation surgery.
Effect of brain shift on the creation of functional atlases for deep brain stimulation surgery.
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DOI：
10.1007/s11548-009-0391-1
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发表时间：
2010-05
影响因子：
3
通讯作者：
D'Haese, Pierre-Francois
中科院分区：
文献类型：
--
作者：
Pallavaram, Srivatsan;Dawant, Benoit M.;Remple, Michael S.;Neimat, Joseph S.;Kao, Chris;Konrad, Peter E.;D'Haese, Pierre-Francois
近年来，许多研究小组试图利用术中获得的信息（如刺激反应或微电极记录）来构建深部脑的功能图谱。在构建这样的图谱时的基本假设是解剖结构在术前成像和术中记录之间不移动。在这项研究中，我们提出的证据表明，这种假设是无效的。我们量化了术前成像和术中记录之间的脑转移对使用术中躯体解剖学记录和刺激反应数据创建功能图谱的影响。共使用了来自24个双侧丘脑底核（subthalamic nucleus，简称丘脑底核）刺激的73个体感点和来自17个双侧丘脑底核刺激的52个眼偏离刺激反应点。使用全自动非刚性配准算法在磁共振成像（MRI）图谱上对这些点进行空间归一化。根据术后CT上可见的气颅量，将每次植入分为低、中或大脑移位。分析每个类别的躯体特征群和刺激图的位置。躯体解剖学数据的大脑移位簇的质心（后、侧、下：3.06、11.27、5.36 mm）位于中等簇的质心（2.90、13.57、4.53 mm）的后、中、下，中等簇的质心位于低移位簇的质心（1.94、13.92、3.20 mm）的后、中、下。坐标参考中间连合点。低-中、中-大和低-大位移星系团质心间的欧氏距离分别为1.68、2.44和3.59 mm。我们发现刺激标测图的位置也有类似的趋势。低和中大位移图上最高概率位置之间的欧几里得距离为4.06 mm。脑深部电刺激（DBS）手术中大脑位移的影响已使用术中躯体解剖学记录以及刺激反应数据得到证明。结果不仅表明，相当大的脑移位发生在微电极记录在DBS，但脑移位影响准确的功能图谱的创建。因此，在构建和使用此类术中数据图谱时以及在使用术中数据验证解剖图谱时必须小心。
In the recent past many groups have tried to build functional atlases of the deep brain using intra-operatively acquired information such as stimulation responses or micro-electrode recordings. An underlying assumption in building such atlases is that anatomical structures do not move between pre-operative imaging and intra-operative recording. In this study, we present evidences that this assumption is not valid. We quantify the effect of brain shift between pre-operative imaging and intra-operative recording on the creation of functional atlases using intra-operative somatotopy recordings and stimulation response data. A total of 73 somatotopy points from 24 bilateral subthalamic nucleus (STN) implantations and 52 eye deviation stimulation response points from 17 bilateral STN implantations were used. These points were spatially normalized on a magnetic resonance imaging (MRI) atlas using a fully automatic non-rigid registration algorithm. Each implantation was categorized as having low, medium or large brain shift based on the amount of pneumocephalus visible on post-operative CT. The locations of somatotopy clusters and stimulation maps were analyzed for each category. The centroid of the large brain shift cluster of the somatotopy data (posterior, lateral, inferior: 3.06, 11.27, 5.36 mm) was found posterior, medial and inferior to that of the medium cluster (2.90, 13.57, 4.53 mm) which was posterior, medial and inferior to that of the low shift cluster (1.94, 13.92, 3.20 mm). The coordinates are referenced with respect to the mid-commissural point. Euclidean distances between the centroids were 1.68, 2.44 and 3.59 mm, respectively for low-medium, medium-large and low-large shift clusters. We found similar trends for the positions of the stimulation maps. The Euclidian distance between the highest probability locations on the low and medium-large shift maps was 4.06 mm. The effect of brain shift in deep brain stimulation (DBS) surgery has been demonstrated using intra-operative somatotopy recordings as well as stimulation response data. The results not only indicate that considerable brain shift happens before micro-electrode recordings in DBS but also that brain shift affects the creation of accurate functional atlases. Therefore, care must be taken when building and using such atlases of intra-operative data and also when using intra-operative data to validate anatomical atlases.
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影响因子：
10.6
作者：
D'Haese, PF;Cetinkaya, E;Dawant, BM
通讯作者：
Dawant, BM
影响因子：
4.8
作者：
Nowinski, Wieslaw L.;Belov, Dmitry;Benabid, Alim-Louis
通讯作者：
Benabid, Alim-Louis
影响因子：
158.5
作者：
Obeso, JA;Guridi, J;Wilkinson, S
通讯作者：
Wilkinson, S
影响因子：
10.6
作者：
Castro, F. Javier Sanchez;Pollo, Claudio;Thiran, Jean-Philippe
通讯作者：
Thiran, Jean-Philippe
DOI：
10.1007/s11548-006-0007-y
发表时间：
2006-03-01
影响因子：
3
作者：
Castro, F. Javier Sanchez;Pollo, Claudio;Thiran, Jean-Philippe
通讯作者：
Thiran, Jean-Philippe