Micro- and nanoscale devices for the investigation of epigenetics and chromatin dynamics.
Micro- and nanoscale devices for the investigation of epigenetics and chromatin dynamics.
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DOI：
10.1038/nnano.2013.195
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发表时间：
2013-10
影响因子：
38.3
通讯作者：
中科院分区：
文献类型：
--
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DNA 是生命赖以生存和传播的蓝图，然而染色质（核酸和蛋白质的动态复合物）在细胞核内的包装和行为方式才刚刚开始被研究。基因组周围的包装和修饰已被证明对细胞行为产生重大影响，进而对人类发育和疾病产生重大影响。然而，研究染色体表观遗传或构象修饰的传统技术具有固有的局限性，因此，人们正在寻求基于微米和纳米级设备的新方法。在这里，我们回顾了这些设备的发展，并探讨了它们在 DNA 和染色质修饰以及高阶染色质结构研究中的应用。
DNA is the blueprint upon which life is based and transmitted, yet the manner in which chromatin, the dynamic complex of nucleic acids and proteins, is packaged and behaves within the cellular nucleus has only begun to be investigated. The packaging and modifications around the genome have been shown to exert significant influence on cellular behaviour and in turn, human development and disease. However, conventional techniques for studying epigenetic or conformational modifications of chromosomes have inherent limitations, and therefore, new methods based on micro- and nanoscale devices have been sought. Here, we review the development of these devices and explore their use in the study of DNA and chromatin modifications and higher order chromatin structure.
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影响因子：
64.8
作者：
Ernst, Jason;Kheradpour, Pouya;Mikkelsen, Tarjei S.;Shoresh, Noam;Ward, Lucas D.;Epstein, Charles B.;Zhang, Xiaolan;Wang, Li;Issner, Robbyn;Coyne, Michael;Ku, Manching;Durham, Timothy;Kellis, Manolis;Bernstein, Bradley E.
通讯作者：
Bernstein, Bradley E.
影响因子：
13.8
作者：
Das, Chandrima;Tyler, Jessica K.;Churchill, Mair E. A.
通讯作者：
Churchill, Mair E. A.
影响因子：
7.4
作者：
Cipriany, Benjamin R.;Zhao, Ruqian;Soloway, Paul D.
通讯作者：
Soloway, Paul D.
DOI：
10.1073/pnas.1007647107
发表时间：
2010-12-14
影响因子：
11.1
作者：
Fanelli, Mirco;Amatori, Stefano;Minucci, Saverio
通讯作者：
Minucci, Saverio
影响因子：
10.8
作者：
Cerf A;Alava T;Barton RA;Craighead HG
通讯作者：
Craighead HG