Key Characteristics of Major Depressive Disorder Occurring in Childhood, Adolescence, Emerging Adulthood, Adulthood.
Key Characteristics of Major Depressive Disorder Occurring in Childhood, Adolescence, Emerging Adulthood, Adulthood.
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发生在儿童期、青春期、成年初期、成年期的重度抑郁症的主要特征。
DOI：
10.1177/2167702612457599
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Gau JM
中科院分区：
文献类型：
--
作者：
Rohde P;Lewinsohn PM;Klein DN;Seeley JR;Gau JM
本文总结了俄勒冈州青少年抑郁症项目中重性抑郁障碍（MDD）的特征，使用816名参与者（56%女性; 89%白色）的数据。对比四个发展阶段（儿童期[5-12.9]，青春期[13-17.9]，成年期[18-23.9]，成年期[24-30]），我们检查了MDD的发病率/复发率，性别，合并症，持续时间和自杀企图。MDD的首次发病率在儿童期低于随后的时期，在成年期高于成年期。累积发病率为51%。儿童期的复发率低于其余时期，这是可比的。女性在所有四个阶段中预测首次发生MDD，但与复发无关。各时期的合并症发生率相当。儿童期MDD持续时间大于其余时期。青少年期的自杀企图率明显高于成年期或成年期。抑郁症研究应该集中在成年期的MDD，青少年自杀行为，性别在成年期的持续作用，以及MDD的普遍性。
This paper summarizes characteristics of major depressive disorder (MDD) in the Oregon Adolescent Depression Project, using data from 816 participants (56% female; 89% White). Contrasting four developmental periods (Childhood [5-12.9], Adolescence [13-17.9], Emerging Adulthood [18-23.9], Adulthood [24-30]), we examine MDD incidence/recurrence, gender, comorbidity, duration, and suicide attempts across periods. MDD first incidence was lower in Childhood compared to subsequent periods, and higher in Emerging Adulthood than Adulthood. Cumulative incidence was 51%. Recurrence was lower during Childhood than remaining periods, which were comparable. Female gender predicted first incident MDD in all four periods but was unassociated with recurrence. Comorbidity rates were comparable across periods. MDD duration was greater in Childhood than remaining periods. Suicide attempt rates were significantly higher during Adolescence than either Emerging Adulthood or Adulthood. Depression research should focus on MDD during Emerging Adulthood, adolescent suicidal behavior, the continuing role of gender into adulthood, and the ubiquity of MDD.