Predicting schizophrenia: findings from the Edinburgh high-risk study
Predicting schizophrenia: findings from the Edinburgh high-risk study
复制标题
DOI：
10.1192/bjp.186.1.18
复制
发表时间：
2005-01-01
影响因子：
10.5
通讯作者：
Lawrie, SM
中科院分区：
文献类型：
--
作者：
Johnstone, EC;Ebmeier, KP;Lawrie, SM
背景精神分裂症是神经发育的假说，在一项前瞻性研究中对年轻人进行了研究，该研究假设精神分裂症的发病风险为10-15%。目的确定疾病前变量，以区分将发展为精神分裂症的高危人群和不发展为精神分裂症的高危人群。方法收集163名有两个亲属精神分裂症的高危青年样本。对他们和36名对照组进行了连续检查。比较精神分裂症患者、正常对照组、正常高危人群和有部分或孤立精神症状的高危人群的基线指标。更易出现孤立或部分精神病症状。精神分裂症患者与非精神分裂症患者在社交焦虑、退缩等分裂型特征上存在差异，整个高危样本在发育和神经心理变量上与对照组存在差异。结论精神分裂症的遗传因素对个体的影响远大于对疾病的影响，且存在部分损害。精神分裂症发展的极有意义的预测因素是在发病前几年可以检测到的。
Background The hypothesis that schizophrenia is neurodevelopmental was investigated in a prospective study of young people with a postulated 10-15% risk for the development of schizophreniaAims To determine premorbid variables distinguishing high-risk people who will go onto develop schizophrenia from those who will not.Method A high-risk sample of 163 young adults with two relatives with schizophrenia was recruited. They and 36 controls were serially examined. Baseline measures were compared between those who did develop schizophrenia, a well control group, a well high-risk group and high-risk participants with partial or isolated psychotic symptoms.Results Of those at high risk, 20 developed schizophrenia within 2 1/2 years. More experienced isolated or partial psychotic symptoms. Those who developed schizophrenia differed from those who did not on social anxiety, withdrawal and other schizotypal features, The whole high-risk sample differed from the control group on developmental and neuropsychological variables.Conclusions The genetic component of schizophrenia affects many more individuals than will develop the illness, and partial impairment can be found in them. Highly significant predictors of the development of schizophrenia are detectable years before onset.