HMGB1 recruits myeloid derived suppressor cells to promote peritoneal dissemination of colon cancer after resection
HMGB1 recruits myeloid derived suppressor cells to promote peritoneal dissemination of colon cancer after resection
复制标题
HMGB1招募骨髓源性抑制细胞促进结肠癌切除后腹膜播散
DOI：
10.1016/j.bbrc.2013.04.109
复制
发表时间：
2013-06-28
影响因子：
3.1
通讯作者：
Tao, Kaixiong
中科院分区：
文献类型：
--
作者：
Li, Wei;Wu, Ke;Tao, Kaixiong
结直肠癌腹膜转移是一个重要的临床问题，导致手术切除后患者预后不良。本研究发现，腹部手术创伤诱导小鼠腹腔高迁移率组框I （HMGB1）高释放。手术创伤后腹腔注射重组HMGB1募集了大量髓源性抑制细胞（MDSCs）。HMGB1 Box-A和吉西他滨可减少术后腹腔内MDSCs的募集，减轻小鼠结肠癌腹膜转移负担。这些结果表明，腹部手术创伤导致腹膜腔释放大量HMGB1，募集大量MDSCs促进治愈性手术后结肠癌腹膜转移。(C) 2013爱思唯尔公司版权所有。
Peritoneal metastasis of colorectal cancer is a major clinical issue and results in poor prognosis for patients after surgical resection. Here, we found that abdominal surgery trauma induced high release of high-mobility group box I (HMGB1) in the peritoneal cavity of mice. Recombinant HMGB1 injected in the peritoneal cavity recruited abundant myeloid derived suppressor cells (MDSCs) after the surgical trauma. HMGB1 Box-A and gemcitabine reduced the recruitment of MDSCs in the peritoneal cavity after the operation and ameliorated the peritoneal metastasis burden of colon cancer in mouse model. These results showed that abdominal surgery trauma leads to a large amount of HMGB1 released in the peritoneal cavity which recruits numerous MDSCs to promote peritoneal metastasis of colon cancer after curative surgery. (C) 2013 Elsevier Inc. All rights reserved.