High-volume production of single and compound emulsions in a microfluidic parallelization arrangement coupled with coaxial annular world-to-chip interfaces
High-volume production of single and compound emulsions in a microfluidic parallelization arrangement coupled with coaxial annular world-to-chip interfaces
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DOI：
10.1039/c2lc40245a
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发表时间：
2012-01-01
期刊：
影响因子：
6.1
通讯作者：
Hatsuzawa, Takeshi
中科院分区：
文献类型：
--
作者：
Nisisako, Takasi;Ando, Takuya;Hatsuzawa, Takeshi
这项研究描述了一种具有同轴环形世界与芯片接口的微流体平台，用于高通量生产具有受控尺寸和内部成分的单一和复合乳液液滴。该生产模块由两个不同的元件组成：一个平面方形芯片，其上圆形排列有许多微流控液滴发生器（MFDG）；以及一个具有同轴环形通道的立方体支撑模块，用于将流体均匀地供应到安装芯片的入口，该模块由带有圆柱体和孔的块组装而成。通过模拟三维流动来评估同轴多个环形通道中的流速分布。例如，通过将 1.5 cm x 1.5 cm 微流控芯片与并行的 144 个 MFDG 和具有两个环形通道的支撑模块耦合，我们可以在 180.0 mL h(-1) 的吞吐量下产生平均直径为 90.7 μm、变异系数 (CV) 为 2.2% 的简单水包油 (O/W) 乳液液滴。此外，我们通过将 1.5 cm x 1.5 cm - 4.5 cm x 4.5 cm 微流控芯片与并行的 32-128 个不同几何形状的 MFDG 耦合并支持具有 3-4 个环形通道的模块，成功演示了 Janus 液滴、双乳液和三乳液的高通量生产。
This study describes a microfluidic platform with coaxial annular world-to-chip interfaces for high-throughput production of single and compound emulsion droplets, having controlled sizes and internal compositions. The production module consists of two distinct elements: a planar square chip on which many copies of a microfluidic droplet generator (MFDG) are arranged circularly, and a cubic supporting module with coaxial annular channels for supplying fluids evenly to the inlets of the mounted chip, assembled from blocks with cylinders and holes. Three-dimensional flow was simulated to evaluate the distribution of flow velocity in the coaxial multiple annular channels. By coupling a 1.5 cm x 1.5 cm microfluidic chip with parallelized 144 MFDGs and a supporting module with two annular channels, for example, we could produce simple oil-in-water (O/W) emulsion droplets having a mean diameter of 90.7 mu m and a coefficient of variation (CV) of 2.2% at a throughput of 180.0 mL h(-1). Furthermore, we successfully demonstrated high-throughput production of Janus droplets, double emulsions and triple emulsions, by coupling 1.5 cm x 1.5 cm - 4.5 cm x 4.5 cm microfluidic chips with parallelized 32-128 MFDGs of various geometries and supporting modules with 3-4 annular channels.