Administration of geniposide ameliorates dextran sulfate sodium-induced colitis in mice via inhibition of inflammation and mucosal damage
Administration of geniposide ameliorates dextran sulfate sodium-induced colitis in mice via inhibition of inflammation and mucosal damage
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京尼平苷通过抑制炎症和粘膜损伤改善右旋糖酐硫酸钠诱导的小鼠结肠炎
DOI：
10.1016/j.intimp.2017.05.033
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发表时间：
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影响因子：
5.6
通讯作者：
Zhang Naisheng
中科院分区：
文献类型：
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作者：
Zhang Zecai;Li Yanxin;Shen Peng;Li Shan;Lu Xiaojie;Liu Jiuxi;Cao Yongguo;Liu Bo;Fu Yunhe;Zhang Naisheng
溃疡性结肠炎（UC）是一种特发性炎症性肠病，不仅影响全世界数百万患者，而且会增加患结肠癌的风险。京尼平苷是一种环烯醚萜苷，具有抗炎、抗氧化等多种生物活性。然而，其对UC的保护功效和作用机制仍不清楚。在本研究中，我们旨在探讨京尼平苷对右旋糖酐硫酸钠（DSS）诱导的小鼠实验性结肠炎的保护作用和机制。结果表明，京尼平苷可减轻DSS引起的体重减轻、疾病活动指数、结肠长度缩短和结肠病理损伤。京尼平苷通过体内外调节 NF-κB 和 PPARγ 通路显着抑制促炎细胞因子。此外，京尼平苷还显着调节 DSS 诱导的小鼠实验性结肠炎和脂多糖 (LPS) 触发的 Caco-2 细胞炎症中 ZO-1 和 occludin 的表达。这些发现表明京尼平苷可能是对抗 UC 的新型天然化学预防剂。
Ulcerative colitis (UC), an idiopathic inflammatory bowel disease, not only affects millions of patients worldwide, but also increases the risk of colon cancer. Geniposide is an iridoid glycoside and has many biological activities such as anti-inflammatory and antioxidant. However, its protective efficacy and mechanism of action against UC are still unclear. In this study, we aimed to investigate the protective effects and mechanisms of geniposide on dextran sulfate sodium (DSS)-induced experimental colitis in mice. The results revealed that geniposide alleviated body weight loss, disease activity index, colon length shortening and colonic pathological damage induced by DSS. Geniposide significantly suppressed pro-inflammatory cytokines by regulating NF-κB and PPARγpathwaysin vivoandin vitro. Furthermore, geniposide also significantly regulated the expressions of ZO-1 and occludin in DSS-induced experimental colitis in mice and lipopolysaccharide (LPS)-triggered inflammation in Caco-2 cells. These findings indicated that geniposide may be a new natural chemopreventive agent to combat UC.