Polycystic ovary syndrome: clinical perspectives and management.
Polycystic ovary syndrome: clinical perspectives and management.
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DOI：
10.1097/00006254-199906000-00024
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发表时间：
1999-06-01
影响因子：
6.2
通讯作者：
Futterweit, W
中科院分区：
文献类型：
--
作者：
Futterweit, W
多囊卵巢综合征（PCOS）是一种常见的高雄激素性疾病，其特征在于通常与高雄激素血症和/或PCOS家族史相关的一系列体征和症状。它通常与高胰岛素血症和胰岛素抵抗有关，这使患者面临可能的潜在并发症的风险，包括2型糖尿病和心血管疾病。临床症状可能很轻微，生化标志物通常包括游离睾酮（T）和可能的硫酸脱氢表雄酮（DHEAS）升高。诊断应寻求在任何妇女与高雄激素的功能，以便适当的治疗可以使用。对于多囊卵巢综合征伴发的多毛症、痤疮或月经过少，通常有良好的治疗反应。增加胰岛素敏感性和减轻肥胖PCOS女性体重的新方法可能有助于改善年轻成年女性这种常见内分泌病的潜在后期并发症。
The polycystic ovary syndrome (PCOS) is a common hyperandrogenic disorder and is characterized by a constellation of signs and symptoms often in association with a family history of hyperandrogenism and/or PCOS. It is often associated with hyperinsulinism and insulin resistance, which puts patients at risk for possible potential complications including type 2 diabetes mellitus and cardiovascular disease. Clinical signs may be subtle, and biochemical markers most often include an elevation of free testosterone (T) and possibly dehydroepiandrosterone sulfate (DHEAS). The diagnosis should be sought in any woman with hyperandrogenic features so that appropriate treatment may be used. There is often a good therapeutic response of the hirsutism, acne, or oligomenorrhea associated with PCOS. The new modalities that increase insulin sensitivity as well as weight reduction in the obese woman with PCOS may potentially be useful in modifying the potential later complications of this common endocrinopathy of young adult women.