Multifaceted leptin network: the molecular connection between obesity and breast cancer.
Multifaceted leptin network: the molecular connection between obesity and breast cancer.
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DOI：
10.1007/s10911-013-9308-2
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发表时间：
2013-12
影响因子：
2.5
通讯作者：
Sharma D
中科院分区：
文献类型：
--
作者：
Saxena NK;Sharma D
高水平的血浆瘦素（一种由脂肪细胞产生的主要脂肪细胞因子）与肥胖状态下脂肪量增加有关。瘦素正成为将肥胖与乳腺癌联系起来的关键候选分子。瘦素通过内分泌、旁分泌和自分泌作用，影响乳房肿瘤发生的各个阶段，从肿瘤起始、原发生长到转移进展。瘦素还主要通过支持内皮细胞的迁移、新生血管生成和维持巨噬细胞和单核细胞的募集来调节肿瘤微环境。多项研究表明，过度活跃的瘦素信号网络导致多种致癌途径同时激活，从而导致肿瘤细胞增殖增强、凋亡减少、间充质表型获得、迁移增强和侵袭潜力增强。此外，瘦素与肥胖状态的其他分子效应物（包括雌激素、IGF-1、胰岛素、VEGF和炎症因子）相互作用的能力进一步增加了其对肥胖状态乳腺肿瘤进展的影响。本文综述了瘦素在乳腺癌中的作用。
High plasma levels of leptin, a major adipocytokine produced by adipocytes, are correlated with increased fat mass in obese state. Leptin is emerging as a key candidate molecule linking obesity with breast cancer. Acting via endocrine, paracrine, and autocrine manner, leptin impacts various stages of breast tumorigenesis from initiation and primary tumor growth to metastatic progression. Leptin also modulates the tumor microenvironment mainly through supporting migration of endothelial cells, neo-angiogenesis and sustaining recruitment of macrophage and monocytes. Various studies have shown that hyperactive leptin-signaling network leads to concurrent activation of multiple oncogenic pathways resulting in enhanced proliferation, decreased apoptosis, acquisition of mesenchymal phenotype, potentiated migration and enhanced invasion potential of tumor cells. Furthermore, the capability of leptin to interact with other molecular effectors of obese state including, estrogen, IGF-1, insulin, VEGF and inflammatory cytokines further increases its impact on breast tumor progression in obese state. This article presents an overview of the studies investigating the involvement of leptin in breast cancer.