Reduced serotonin-1A receptor binding in social anxiety disorder
Reduced serotonin-1A receptor binding in social anxiety disorder
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DOI：
10.1016/j.biopsych.2006.05.022
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发表时间：
2007-05-01
影响因子：
10.6
通讯作者：
Tauscher, Johannes
中科院分区：
文献类型：
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作者：
Lanzenberger, Rupert R.;Mitterhauser, Markus;Tauscher, Johannes
背景：5-羟色胺-1A (5-HT1A) 敲除小鼠的研究结果和之前的人类正电子发射断层扫描 (PET) 研究结果表明，5-HT1A 受体在正常状态焦虑以及某些焦虑症中发挥作用。本研究的目的是调查社交焦虑障碍 (SAD) 中的 5-HT1A 受体结合电位 (BP)。方法：使用 PET 和 [羰基-C-11]WAY-100635，我们将 12 名未接受药物治疗的男性 SAD 患者与 18 名健康对照受试者 (HQ) 进行比较。进行了多变量方差分析，其中所有区域血压值作为因变量，年龄和四个放射化学变量作为协变量。结果：我们发现 SAD 患者的几个边缘和旁边缘区域的 5-HT1A 血压显着降低，但在海马中则不然 (p=.234)。5-HT1A 结合的差异在杏仁核中最为显着 (-21.4%；p =.003)。SAD 患者的前扣带皮层的 5-HT1A 血压也降低了 20% 以上。 =.004)、岛叶 (p =.003) 和中缝背核 (p =.030)。结论：SAD 患者杏仁核和中额叶区域 5-HT1A 结合较低，这与 1) 5-HT1A 敲除小鼠焦虑升高的临床前发现一致，2) 之前在健康志愿者中进行的 PET 研究显示 5-HT1A 之间存在负相关。 BP 和状态焦虑，以及 3) 另一项针对惊恐障碍患者的人类 PET 研究显示 5-HT1A 结合减少，从而证实了 5-HT1A 受体作为治疗人类焦虑障碍的靶点的潜在有效性。
Background: Results from studies in serotonin-1A (5-HT1A) knockout mice and previous positron emission tomography (PET) studies in humans imply a role for 5-HT1A receptors in normal state anxiety as well as in certain anxiety disorders. The objective of this study was to investigate 5-HT1A receptor binding potential (BP) in social anxiety disorder (SAD).Methods: Using PET and [carbonyl-C-11]WAY- 100635, we compared a homogeneous group of 12 unmedicated, male SAD patients with 18 healthy control subjects (HQ. A multivariate ANOVA with all regional BP values as dependent variables, age and four radiochemical variables as covariates was performed.Results: We found a significantly lower 5-HT1A BP in several limbic and paralimbic areas but not in the hippocampus (p=.234) of SAD patients. The difference in 5-HT1A binding was most significant in the amygdala (-21.4%; p =.003). There was also a more than 20% lower 5-HT1A BP of SAD patients in the anterior cingulate cortex (p =.004), insula (p =.003), and dorsal raphe nuclei (p =.030).Conclusions: The lower 5-HT1A binding in the amygdala and mesiofrontal areas of SAD patients is consistent with 1) preclinical findings of elevated anxiety in 5-HT1A knockout mice, 2) a previous PET study in healthy volunteers showing an inverse correlation between 5-HT1A BP and state anxiety, and 3) another human PET study in patients with panic disorder showing reduced 5-HT1A, binding, thus corroborating the potential validity of 5-HT1A receptors as targets in the treatment of human anxiety disorders.