Normal neuroanatomical variation due to age: The major lobes and a parcellation of the temporal region
Normal neuroanatomical variation due to age: The major lobes and a parcellation of the temporal region
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DOI：
10.1016/j.neurobiolaging.2005.05.023
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发表时间：
2005-10-01
影响因子：
4.2
通讯作者：
Damasio, H
中科院分区：
文献类型：
--
作者：
Allen, JS;Bruss, J;Damasio, H
我们使用高分辨率MRI研究大脑主要叶（额叶、顶叶、颞叶、枕叶）和颞叶主要部分（颞极、上级颞回、颞下区、海马旁回、杏仁核、海马）的灰质和白色物质老化。受试者包括87名年龄在22岁至88岁之间的成年人。在连续的1.5 mm冠状切片上手工追踪感兴趣区域。一般来说，大脑的灰质随着年龄的增长而线性下降，导致30岁至70岁之间下降约9.1-9.8%，到80岁时下降11.3-12.3%。相反，白色物质的体积增加，直到50年代中期，之后它以加速的速度下降。在70岁时，白色物质体积仅比30岁时减少5.6-6.4%，但到80岁时，三次回归模型预测减少将为21.6- 25.0%。多变量分析表明，额叶灰质与年龄的相关性最强，而枕叶灰质和白色物质的相关性最小。海马体积的减少最好用三次回归模型而不是线性模型来建模。在任何感兴趣的区域均未发现老化的性别差异。(c)2005年爱思唯尔公司All rights reserved.
We used high-resolution MRI to investigate gray and white matter aging in the major lobes of the cerebrum (frontal, parietal, temporal, occipital) and the major sectors of the temporal lobe (temporal pole, superior temporal gyrus, infero-temporal region, parahippocampal gyrus, amygdala, hippocampus). Subjects included 87 adults between the ages of 22 and 88 years. Regions of interest were hand-traced on contiguous 1.5 mm coronal slices. For the cerebrum in general, gray matter decreased linearly with age, resulting in a decline of about 9.1-9.8% between the ages of 30 and 70 years, and a decline of 11.3-12.3% by the age of 80. In contrast, white matter volume increased until the mid-50s, after which it declined at an accelerated rate. At 70 years, white matter volume was only 5.6-6.4% less than at 30 years, but by age 80, a cubic regression model predicted that the decrease would be 21.6-25.0%. Multivariate analyses indicate that the frontal gray matter was most strongly associated with age, while occipital gray and white matter were least associated. Reduction in volume in the hippocampus was best modeled by a cubic regression model rather than a linear model. No sex differences in aging were found for any regions of interest. (c) 2005 Elsevier Inc. All rights reserved.