Lessons from mice without telomerase.
Lessons from mice without telomerase.
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来自没有端粒酶的小鼠的教训。
DOI：
10.1083/jcb.139.2.309
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Lansdorp,PM
中科院分区：
文献类型：
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作者：
Lansdorp,PM
几乎所有恶性肿瘤都有端粒酶活性，这一观察结果已被端粒酶对恶性肿瘤进展至关重要的假设所解释。令人惊讶的是，在不同的转化和永生化实验中，没有端粒酶RNA基因和端粒酶活性的小鼠细胞与正常细胞没有区别。然而，对端粒酶缺失细胞中染色体的详细分析揭示了端粒酶在正常生物学中的作用，并为未来的研究提出了明确的问题。
The observation that almost all malignant cancers have telomerase activity has been explained by the assumption that telomerase is crucial for the progression of malignancy. Surprisingly, cells from mice without a functional telomerase RNA gene and no telomerase activity are indistinguishable from normal cells in different transformation and immortalization assays. However, detailed analysis of chromosomes in telomerase null cells has revealed multiple defects that point to the role of telomerase in normal biology and raise well-defined questions for future research.