A feasibility study: Evaluation of radiofrequency ablation therapy to hepatocellular carcinoma using image registration of preoperative and postoperative CT
A feasibility study: Evaluation of radiofrequency ablation therapy to hepatocellular carcinoma using image registration of preoperative and postoperative CT
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DOI：
10.1016/j.acra.2006.05.011
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发表时间：
2006-08-01
影响因子：
4.8
通讯作者：
Ito, Katsuhide
中科院分区：
文献类型：
--
作者：
Fujioka, Chikako;Horiguchi, Jun;Ito, Katsuhide
基本原理和目标。肝细胞癌（HCC）射频消融（RFA）的治疗反应通常通过比较射频消融前后的计算机断层扫描（CT）来评估。然而，有时很难判断是否保证了正常肝组织的消融边界（即5-10 mm）。本研究的目的是评估rfa前后CT融合图像的可行性。材料与方法。包括尺寸为13 +/- 5 mm（范围4-23 mm）的hcc （n = 20）。rfa前CT采用静脉动态CT动脉期（n = 17）、CT动脉造影（n = 2）、CT肝动脉造影（n = 1）。使用自动图像配准软件（n = 20）和人工分割技术（n = 4），结合rfa后CT（静脉CT平衡期）创建融合图像。自动图像配准和手动图像分割分别耗时约2-3分钟和5分钟。在所有情况下，创建融合图像所需的总时间都小于10分钟。融合图像可以更容易地了解肿瘤与消融区之间的关系，有助于判断是否确保了消融边界。融合RFA前后的CT图像被认为是评估RFA治疗HCC的可行方法。
Rationale and Objectives. The therapeutic response to radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) often is evaluated by comparing pre- and post-RFA computed tomography (CT). However, judgment about whether an ablative margin, ie, 5-10 mm of normal hepatic tissue, is ensured sometimes is difficult. The aim of this study is to assess the feasibility of fusion images of pre- and post-RFA CT.Materials and Methods. HCCs (n = 20) sized 13 +/- 5 mm (range, 4-23 mm) were included. For pre-RFA CT, the arterial phase of intravenous dynamic CT (n = 17), CT arterioportography (n = 2), and CT hepatic arteriography (n = 1) was used. Using automatic image registration software (n = 20) and a manual segmentation technique (n = 4), fusion images were created in combination with post-RFA CT (equilibrium phase of intravenous CT).Results. Automatic image registration and manual segmentation technique took approximately 2-3 and 5 minutes, respectively. Total time required for the creation of fusion images was less than 10 minutes in all cases. Fusion images enabled easier understanding of the relationship between the tumor and ablation zone, helping judge whether an ablative margin was ensured.Conclusion. Fusion of pre- and post-RFA CT images is considered a feasible toot in the evaluation of RFA therapy for HCC.