New developments in photodynamic therapy
New developments in photodynamic therapy
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DOI：
10.1007/s00105-012-2513-x
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发表时间：
2013-05-01
期刊：
影响因子：
--
通讯作者：
Karrer, S.
中科院分区：
文献类型：
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作者：
Kohl, E.;Karrer, S.
我们回顾了近年来光动力疗法的新进展。自 2009 年以来，两种新型光敏剂、自粘式 5-氨基乙酰丙酸 (ALA) 贴片和 5-氨基乙酰丙酸纳米乳制剂已被批准用于治疗光化性角化病。使用烧蚀点阵激光进行预处理可增强光敏剂的渗透性，并能够在肢端病变和局部癌化皮肤中强化 PDT。多项临床试验已经证明了光动力疗法的皮肤再生作用，同时其潜在的作用机制也已得到阐明。光动力疗法在治疗和预防皮肤癌高风险器官移植受者的光化性角化病方面已显示出疗效。我们还总结了日光介导的光动力疗法的现有研究结果。
We review new developments in recent years in photodynamic therapy. Since 2009 two new photosensitizers, a self-adhesive 5-aminolevulinic acid (ALA) patch and a nanoemulsion formulation of 5-aminolevulinic acid have been approved for the treatment of actinic keratoses. Pretreatment with ablative fractional lasers enhances penetration of the photosensitizer and enables intensified PDT in acral lesions and in field-cancerized skin. Several clinical trials have demonstrated the skin-rejuvenating effects of photodynamic therapy, while the underlying mechanisms of action have been clarified. The efficacy of photodynamic therapy has been shown in the treatment and prophylaxis of actinic keratoses in organ transplant recipients at high risk for developing skin cancer. We also summarize the results of available studies on daylight-mediated photodynamic therapy.