Metabolic adaptations of the nephron in renal disease.
Metabolic adaptations of the nephron in renal disease.
复制标题
肾脏疾病中肾单位的代谢适应。
DOI：
10.1038/ki.1986.10
复制
发表时间：
1986
影响因子：
19.6
通讯作者：
Stokes,TJ
中科院分区：
文献类型：
--
作者：
Klahr,S;Schwab,SJ;Stokes,TJ
形态学和生理学研究表明，不同的肾单位节段在功能和代谢上是不同的。了解肾脏代谢的重大进展需要改进的技术来研究肾脏组织异质性的问题。肾脏疾病中肾脏内的异质性程度可能会增加，因为病理过程是多次局灶性的，或者它们在某些区域产生组织学变化，在肾脏的其他区域产生适应性变化。因此，方法学问题阻碍了肾脏疾病中肾脏代谢的研究，特别是在肾单位水平上。大多数代谢研究都是在肾脏疾病的实验动物模型中进行的。本文综述了尿路梗阻、肾毒性或缺血性急性肾功能衰竭以及肾质量降低的慢性模型中发生的肾代谢变化。现有的信息是有限的，我们对肾脏疾病的肾代谢的理解存在重大差距是显而易见的。
Morphological and physiological studies have shown that various nephron segments are different functionally and metabolically. Major advances to understand renal metabolism have required improved techniques to study the problem of tissue heterogeneity in the kidney. The degree of heterogeneity within the kidney in renal disease may increase because pathological processes are many times focal or they produce histological changes in certain areas and adaptive changes in other zones of the kidney. Hence, methodological problems have hampered the studies of renal metabolism, particularly at the nephron level, in kidney diseases. Most metabolic studies have been done in experimental animal models of renal disease. This article provides an overview of changes in renal metabolism that occur in urinary tract obstruction, nephrotoxic or ischemic-induced acute renal failure, and in chronic models of reduced renal mass. The information available is limited and the existence of major gaps in our understanding of renal metabolism in diseases of the kidney is evident.