PIEZOELECTRIC CERAMIC IMPLANTS - INVIVO RESULTS
PIEZOELECTRIC CERAMIC IMPLANTS - INVIVO RESULTS
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DOI：
10.1002/jbm.820150114
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
COFFEEN, WW
中科院分区：
文献类型：
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作者：
PARK, JB;KELLY, BJ;COFFEEN, WW
使用电刺激（压电）和非活性（非极化）测试植入物评价钛酸钡（BaTiO 3）陶瓷直接替代硬组织的适用性。纹理圆柱形标本，其中一半的压电在高电场中的极化，被植入到皮质的股骨中段区域的狗的不同时间。采用力学、显微放射学和组织学技术研究了植入材料的界面愈合和生物相容性。BaTiO 3陶瓷显然显示出非常高的生物相容性，这一点可以通过植入物-组织界面处不存在炎症或异物反应来证明。该材料及其表面孔隙率允许高度骨长入，如显微放射照相和高度界面拉伸强度所证明。压电和电中性种植体-组织界面之间没有发现差异。可能的原因进行了讨论。BaTiO 3优异的机械性能、其上级生物相容性以及骨与其形成强机械结合的能力，使该材料成为进一步测试硬组织替代物的新候选材料。
The suitability of barium titanate (BaTiO3) ceramic for direct substitution of hard tissues was evaluated using electrically stimulated (piezoelectric) and inactive (nonpolarized) test implants. Textured cylindrical specimens, half of them made piezoelectric by polarization in a high electric field, were implanted into the cortex of the midshaft region of the femora of dogs for various periods of time. Interfacial healing and biocompatibility of the implant material were studied using mechanical, microradiographical and histological techniques. BaTiO3 ceramic apparently shows a very high degree of biocompatibility as evidenced by the absence of inflammatory or foreign body reactions at the implant-tissue interface. The material and its surface porosity allowed a high degree of bone ingrowth as evidenced by microradiography and a high degree of interfacial tensile strength. No difference was found between the piezoelectric and the electrically neutral implant-tissue interfaces. Possible reasons for this are discussed. The excellent mechanical properties of BaTiO3, its superior biocompatibility and the ability of bone to form a strong mechanical bond with it, makes this material a new candidate for further tests for hard tissue replacement.