Effect of asiaticoside on endothelial cells in hypoxia‑induced pulmonary hypertension.
Effect of asiaticoside on endothelial cells in hypoxia‑induced pulmonary hypertension.
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积雪草苷对缺氧肺动脉高压内皮细胞的影响
DOI：
10.3892/mmr.2017.8254
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发表时间：
2018-03
影响因子：
3.4
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Wang X;Cai X;Wang W;Jin Y;Chen M;Huang X;Zhu X;Wang L
肺动脉高压（PH）是一种慢性进行性疾病，治疗选择有限。PH的确切病因和发病机制仍有待阐明，然而有新的证据表明异常内皮细胞（EC）凋亡和EC功能障碍参与PH的起始。积雪草苷（AS）是从药用植物积雪草中提取的皂苷单体，本课题组前期研究发现，其可能通过阻断转化生长因子-β1/SMAD家族成员2/3信号通路而发挥预防缺氧性肺动脉高压（hypoxic PH）的作用。本研究表明，AS可阻止缺氧性PH的发展，逆转已建立的缺氧性PH，AS可通过增强丝氨酸/苏氨酸特异性蛋白激酶/eNOS的磷酸化激活一氧化氮（NO）介导的信号，从而促进NO的产生，阻止缺氧诱导的内皮细胞凋亡。所有这些结果表明，AS可能是一个潜在的治疗选择缺氧PH患者由于其对内皮细胞的活力和功能的影响。
Pulmonary hypertension (PH) is a chronic progressive disease with limited treatment options. The exact etiology and pathogenesis of PH remain to be elucidated, however there is novel evidence that implicates abnormal endothelial cells (ECs) apoptosis and dysfunction of ECs to be involved in the initiation of PH. Asiaticoside (AS) is a saponin monomer extracted from a medicinal plant called Centella asiatica, which had a preventing effect of hypoxia-induced pulmonary hypertension (hypoxic PH) by blocking transforming growth factor-β1/SMAD family member 2/3 signaling in our previous study. The present study demonstrated that AS can prevent the development of hypoxic PH and reverse the established hypoxic PH. AS may activate the nitric oxide (NO)-mediated signals by enhancing the phosphorylation of serine/threonine-specific protein kinase/eNOS, thus promoting NO production, and prevent ECs from hypoxia-induced apoptosis. All these findings imply that AS may be a potential therapeutic option for hypoxic PH patients due to its effect on the vitality and function of endothelial cells.
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