Control of atrial natriuretic factor release from a rat heart-lung preparation.
Control of atrial natriuretic factor release from a rat heart-lung preparation.
复制标题
控制大鼠心肺制剂中心房钠尿因子的释放。
DOI：
10.1152/ajpregu.1987.252.3.r498
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Dietz,JR
中科院分区：
文献类型：
--
作者：
Dietz,JR
这些实验检测了改变静脉回流、主动脉压或灌注钠浓度对大鼠心肺制剂中房钠素（ANF）释放的影响。各时间段灌注ANF浓度变化（δ ANF）作为ANF分泌的指标。将静脉回流库的高度从心脏上方2-3 cm提高到5-7 cm，使δ ANF从88 +/- 19增加到748 +/- 154 pg X ml-1 X 10 min-1 （P < 0.01, n = 7）。在不增加储层高度的对照实验中，δ ANF不变（65 +/- 35 vs 43 +/- 26 pg X ml-1 X 10 min-1, n = 6）。主动脉压从60 mmHg增加到100 mmHg， ANF从43 +/- 10增加到107 +/- 20 pg X ml-1 X 15 min-1 （P < 0.05, n = 6）。分别以钠浓度为132 +/- 1、144 +/- 2、166 +/- 1 meq/l的溶液灌注心肺制剂各组（n = 8/组）。δ ANF分别为45 +/- 14、50 +/- 17和52 +/- 22 pg X ml-1 X 10 min-1。这些数值无显著差异。这些结果表明，ANF在控制血容量和血压方面起作用，但不支持ANF在控制血浆钠浓度方面的作用。
These experiments examined the effects of altering venous return, aortic pressure, or perfusate sodium concentration on the release of atrial natriuretic factor (ANF) from a rat heart-lung preparation. Changes in perfusate ANF concentration during each time period (delta ANF) were used as an index of ANF secretion. Raising the height of the venous return reservoir from 2-3 to 5-7 cm above the heart increased delta ANF from 88 +/- 19 to 748 +/- 154 pg X ml-1 X 10 min-1 (P less than 0.01, n = 7). In control experiments where the height of the reservoir was not increased, delta ANF was unchanged (65 +/- 35 vs. 43 +/- 26 pg X ml-1 X 10 min-1, n = 6). Increasing aortic pressure from 60 to 100 mmHg increased ANF from 43 +/- 10 to 107 +/- 20 pg X ml-1 X 15 min-1 (P less than 0.05, n = 6). Separate groups of heart-lung preparations were perfused with solutions with sodium concentrations of 132 +/- 1, 144 +/- 2, or 166 +/- 1 meq/l (n = 8/group). delta ANF was 45 +/- 14, 50 +/- 17, and 52 +/- 22 pg X ml-1 X 10 min-1, respectively. These values were not significantly different. These results suggest that ANF plays a role in the control of blood volume and blood pressure but do not support a role for ANF in the control of plasma sodium concentration.