SUSCEPTIBILITY OF THE DEVELOPING RAT GUSTATORY SYSTEM TO THE PHYSIOLOGICAL-EFFECTS OF DIETARY-SODIUM DEPRIVATION
SUSCEPTIBILITY OF THE DEVELOPING RAT GUSTATORY SYSTEM TO THE PHYSIOLOGICAL-EFFECTS OF DIETARY-SODIUM DEPRIVATION
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DOI：
10.1113/jphysiol.1987.sp016830
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发表时间：
1987-12-01
影响因子：
5.5
通讯作者：
HILL, DL
中科院分区：
文献类型：
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作者：
HILL, DL
1.多纤维反应记录从鼓索神经在大鼠喂养的NaCl缺乏的饮食或NaCl-充满的饮食从3天后的概念，至少28天后出生。反应也记录在大鼠喂养NaCl缺乏的饮食在早期发展，然后喂养NaCl-充满饮食1-20天，从出生后28天开始，在大鼠喂养NaCl缺乏的饮食只作为成年人。上皮钠转运阻滞剂，阿米洛利，被用来研究味觉感受器膜功能的饮食的生理效应，并表征参与功能恢复的事件。2.舌应用的钠盐的反应增加，增加刺激浓度，然而，反应幅度减少在大鼠喂养的NaCl缺乏的饮食在早期发展相比，控制。对非钠盐和非盐刺激的反应与对照组相似。阿米洛利不能有效抑制剥夺大鼠对NaCl的味觉反应，但能有效抑制对照大鼠对NaCl的味觉反应，但至少抑制50%。在早期剥夺大鼠喂食NaCl-充满的饮食后，对钠盐的反应在15天内恢复到对照水平。在此期间，阿米洛利的敏感性也随之降低。3.从妊娠早期到成年，喂食NaCl缺乏饮食的大鼠的反应与年轻的剥夺大鼠相似，因为钠反应低于对照组。然而，大鼠剥夺只有成年人是类似的控制。4.发育中大鼠的外周味觉系统对饮食中的钠含量敏感，并且是“可塑性的”，因为早期的影响可以通过限制饮食中的钠来逆转。然而，一旦饮食控制超过敏感期，功能性味觉反应似乎不受影响。
1. Multifibre responses were recorded from the chorda tympani nerve in rats fed either a NaCl-deficient diet or a NaCl-replete diet from 3 days post-conception to at least 28 days post-natal. Responses were also recorded in rats fed the NaCl-deficient diet during early development and then fed the NaCl-replete diet for 1-20 days beginning at 28 days post-natal, and in rats fed the NaCl-deficient diet only as adults. The epithelial sodium transport blocker, amiloride, was used to study the physiological effects of the diet on taste receptor membrane function and to characterize the events involved in recovery of function. 2. Responses to lingual application of sodium salts increased with increasing stimulus concentration; however, response magnitudes were reduced in rats fed the NaCl-deficient diet during early development compared to controls. Responses to non-sodium salts and non-salt stimuli were similar to controls. Amiloride was ineffective insuppressing taste responses to NaCl in deprived rats but effectively suppressed responses in controls but at least 50%. After early-deprived rats were fed a NaCl-replete diet, responses to sodium salts recovered to control levels within 15 days. There was a concomitant decrease in amiloride sensitivity during this period. 3. Rats fed the NaCl-deficient diet from early gestation through adulthood had responses similar to younger deprived rats in that sodium responses were lower than controls. However, rats deprived only as adults were similar to controls. 4. The peripheral gustatory system in developing rats is susceptible to the sodium content of the diet and is ''plastic'' in that early effects can be reversed by restricting dietary sodium. Once dietary manipulations are instituted past a sensitive period, however, functional taste responses seem unaffected.