Proposed Diagnostic Criteria for Obstructive Meibomian Gland Dysfunction
Proposed Diagnostic Criteria for Obstructive Meibomian Gland Dysfunction
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DOI：
10.1016/j.ophtha.2009.04.037
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发表时间：
2009-11-01
期刊：
影响因子：
13.7
通讯作者：
Amano, Shiro
中科院分区：
文献类型：
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作者：
Arita, Reiko;Itoh, Kouzo;Amano, Shiro
用途：比较阻塞性睑板腺功能障碍（MGD）患者与正常对照者的临床表现，并提出阻塞性MGD的诊断标准。设计：横断面观察性病例系列。参与者：53例患者的53只眼（18名男性，35名女性;年龄[平均值+/-标准差] 71.4 +/- 10.0岁）和60名健康志愿者的60只眼方法：根据存在的症状数量，将眼部症状从0到14进行评分。根据存在的异常数量，眼睑边缘异常评分为0 - 4分。根据非接触式睑板造影术（meibo评分），对睑板腺变化进行0 - 6分评分。表浅点状角膜病变（SPK）评分为0 - 3分。根据体积和质量，将眼睑从0到3分级。泪膜的产生通过Schirmer试验进行评价。受试者操作特征曲线计算曲线下面积（AUC）来描述每个参数区分阻塞性MGD和正常眼的准确性。主要结果测量：眼部症状评分、眼睑边缘异常评分、meibo评分、睑球评分、SPK评分、泪膜破裂时间（BUT）和Schirmer值。阻塞性MGD组的眼部症状评分、睑缘异常评分、睑缘评分、睑脂评分和SPK评分均显著高于对照组（P
Purpose: To compare clinical findings between patients with obstructive meibomian gland dysfunction (MGD) and normal controls and to propose diagnostic criteria for obstructive MGD.Design: Cross-sectional, observational case series.Participants: Fifty-three eyes of 53 patients (18 men, 35 women; age [mean +/- standard deviation] 71.4 +/- 10.0 years) who were diagnosed with obstructive MGD and 60 eyes of 60 healthy volunteers (22 men, 38 women; 71.0 +/- 9.3 years) as a control group.Methods: Ocular symptoms were scored from 0 to 14 according to the number of existing symptoms. Lid margin abnormality was scored from 0 to 4 depending on the number of existing abnormalities. Meibomian gland changes were scored from 0 to 6 based on noncontact meibography (meibo-score). Superficial punctuate keratopathy (SPK) was scored from 0 to 3. Meibum was graded from 0 to 3 depending on the volume and quality. Tear film production was evaluated by Schirmer's test. Receiver operating characteristic curves with calculations of area under the curve (AUC) were used to describe the accuracy of each parameter to differentiate obstructive MGD from normal eyes.Main Outcome Measures: Ocular symptom score, lid margin abnormality score, meibo-score, meibum score, SPK score, tear film breakup time (BUT), and the Schirmer value.Results: Ocular symptom score, lid margin abnormality score, meibo-score, meibum score, and SPK score were significantly higher in the obstructive MGD group than in the control group (P