Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China
Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China
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中国 H7N9 流感多种基因型的连续重组
DOI：
10.1016/j.chom.2013.09.001
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发表时间：
2013-10-16
影响因子：
30.3
通讯作者：
Jiang, Taijiao
中科院分区：
文献类型：
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作者：
Wu, Aiping;Su, Chunhu;Jiang, Taijiao
最初的遗传特征表明，导致中国当前爆发的流感（H7N9）病毒是新颖的替代品。然而，对它们进化的途径，尤其是多种病毒基因型的产生知之甚少。在这里，我们报告了在中国最近在中国的流感监测工作中，对从人，家禽和野生鸟类中分离出的45 H7N9和42 H9N2病毒的全基因组序列数据的深入进化分析。我们的分析表明，H7N9病毒是由至少两个步骤进行的两个步骤，涉及不同宿主中不同H9N2供体病毒的顺序重新分类。第一次放置可能发生在2012年初的野鸟中，第二个是在中国东部的家禽中。我们的研究确定了中国生成多种H7N9基因型的途径，并强调了监测多个来源以有效监视潜在流感疫情的重要性。
Initial genetic characterizations have suggested that the influenza A (H7N9) viruses responsible for the current outbreak in China are novel reassortants. However, little is known about the pathways of their evolution and, in particular, the generation of diverse viral genotypes. Here we report an in-depth evolutionary analysis of whole-genome sequence data of 45 H7N9 and 42 H9N2 viruses isolated from humans, poultry, and wild birds during recent influenza surveillance efforts in China. Our analysis shows that the H7N9 viruses were generated by at least two steps of sequential reassortments involving distinct H9N2 donor viruses in different hosts. The first reassortment likely occurred in wild birds and the second in domestic birds in east China in early 2012. Our study identifies the pathways for the generation of diverse H7N9 genotypes in China and highlights the importance of monitoring multiple sources for effective surveillance of potential influenza outbreaks.