Diet after diagnosis and the risk of prostate cancer progression, recurrence, and death (United States)
Diet after diagnosis and the risk of prostate cancer progression, recurrence, and death (United States)
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DOI：
10.1007/s10552-005-0413-4
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发表时间：
2006-03-01
影响因子：
2.3
通讯作者：
Giovannucci, EL
中科院分区：
文献类型：
--
作者：
Chan, JM;Holick, CN;Giovannucci, EL
Objectives我们研究了诊断后的饮食和癌症进展的风险在一个队列的男性前列腺癌的卫生专业人员随访Study.Methods我们观察了392进展的结果在1,202名男性诊断为偶发局部/区域前列腺癌之间的1986年和1996年。男性在诊断前后完成了前瞻性饮食调查，并随访至2000年。我们使用考克斯比例风险回归模型，对诊断后食用红肉、谷物、蔬菜、水果、牛奶、西红柿、番茄酱料和鱼作为疾病进展的预测因子进行了研究，该模型调整了总能量、年龄、临床因素、结果诊断后鱼消费量最高与最低四分位数的男性的进展的多变量风险比（HR）为0.73（95% CI 0.52-1.02）;番茄酱料的可比HR为0.56（95% CI 0.38-0.82）。我们观察到鱼和番茄酱料与疾病进展风险的反向线性关系（对于每周增加两份鱼和番茄酱料，分别为HR = 0.83，p值= 0.006和HR = 0.80，p值= 0.04）。牛奶和新鲜番茄的消费量与风险的小幅升高有关。结论这些数据表明，诊断后的饮食可能会影响前列腺癌的临床进程，鱼和番茄酱料可能会提供一些保护，防止疾病的进展。
Objectives We examined post-diagnostic diet and risk of cancer progression in a cohort of men with prostate cancer from the Health Professionals Follow-up Study.Methods We observed 392 progression outcomes among 1,202 men diagnosed with incident localized/regional prostate cancer between 1986 and 1996. Men completed prospective dietary surveys before and after diagnosis and were followed through 2000. We examined post-diagnostic consumption of red meat, grains, vegetables, fruits, milk, tomatoes, tomato sauce, and fish as predictors of progression using Cox proportional hazard regression models adjusted for total energy, age, clinical factors, and pre-diagnostic diet.Results Men in the highest versus lowest quartile of post-diagnostic fish consumption had a multivariate hazard ratio (HR) of progression of 0.73 (95% CI 0.52-1.02); the comparable HR for tomato sauce was 0.56 (95% CI 0.38-0.82). We observed inverse linear relationships for fish and tomato sauce and risk of progression (HR = 0.83, p-value = 0.006 and HR = 0.80, p-value = 0.04 for a two serving/week increase of fish and tomato sauce, respectively). Milk and fresh tomato consumption were associated with small elevations in risk.Conclusions These data suggest that diet after diagnosis may influence the clinical course of prostate cancer, and fish and tomato sauce may offer some protection against disease progression.