Splicing of α1A subunit gene generates phenotypic variants of P- and Q-type calcium channels
Splicing of α1A subunit gene generates phenotypic variants of P- and Q-type calcium channels
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DOI：
10.1038/8070
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发表时间：
1999-05-01
影响因子：
25
通讯作者：
Snutch, TP
中科院分区：
文献类型：
--
作者：
Bourinet, E;Soong, TW;Snutch, TP
在哺乳动物神经系统中，p型和q型钙通道介导神经递质在许多突触中的释放。钙通道与发作性共济失调、癫痫和家族性偏头痛等疾病的病因有关，并且与天然P型和q型通道具有一些相同的特性。然而，α (1A)与P型和q型通道之间的确切关系尚不清楚。在这里，我们报告了α (1A)亚基基因的选择性剪接导致具有不同动力学，药理学和调节特性的通道。总的来说，结果表明α (1A)基因的选择性剪接产生p型和q型通道以及多种表型变异。
P-type and Q-type calcium channels mediate neurotransmitter release at many synapses in the mammalian nervous system. The or,, calcium channel has been implicated in the etiologies of conditions such as episodic ataxia, epilepsy and familial migraine, and shares several properties with native P- and Q-type channels. However, the exact relationship between alpha(1A) and P- and Q-type channels is unknown. Here we report that alternative splicing of the alpha(1A) subunit gene results in channels with distinct kinetic, pharmacological and modulatory properties. Overall, the results indicate that alternative splicing of the alpha(1A) gene generates P-type and Q-type channels as well as multiple phenotypic variants.