Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators.
Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators.
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人类的X和Y染色体是从一对普通的常染色体进化而来的，但数百万年前，Y染色体遭到了遗传衰退的破坏，只有3%的祖先基因幸存下来。我们重建了八种哺乳动物Y染色体的进化，以确定基因内容的偏差和保留幸存祖先基因的选择压力。我们的研究结果表明，生存是非随机的，在两种情况下，收敛胎盘和有袋类哺乳动物。我们的结论是，Y染色体的基因内容成为专门通过选择，以保持祖先剂量的同源X-Y基因对，广泛表达的转录，翻译和蛋白质稳定性的调节器的功能。我们认为，除了在睾丸决定和精子发生中的作用外，Y染色体对男性的生存能力至关重要，在特纳综合征和健康和疾病的性别表型差异中起着不受重视的作用。
The human X and Y chromosomes evolved from an ordinary pair of autosomes, but millions of years ago genetic decay ravaged the Y chromosome, and only three percent of its ancestral genes survived. We reconstructed the evolution of the Y chromosome across eight mammals to identify biases in gene content and the selective pressures that preserved the surviving ancestral genes. Our findings indicate that survival was non-random, and in two cases, convergent across placental and marsupial mammals. We conclude that the Y chromosome's gene content became specialized through selection to maintain the ancestral dosage of homologous X-Y gene pairs that function as broadly expressed regulators of transcription, translation and protein stability. We propose that beyond its roles in testis determination and spermatogenesis, the Y chromosome is essential for male viability, and plays unappreciated roles in Turner syndrome and in phenotypic differences between the sexes in health and disease.
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影响因子：
14.9
作者：
Flicek P;Amode MR;Barrell D;Beal K;Billis K;Brent S;Carvalho-Silva D;Clapham P;Coates G;Fitzgerald S;Gil L;Girón CG;Gordon L;Hourlier T;Hunt S;Johnson N;Juettemann T;Kähäri AK;Keenan S;Kulesha E;Martin FJ;Maurel T;McLaren WM;Murphy DN;Nag R;Overduin B;Pignatelli M;Pritchard B;Pritchard E;Riat HS;Ruffier M;Sheppard D;Taylor K;Thormann A;Trevanion SJ;Vullo A;Wilder SP;Wilson M;Zadissa A;Aken BL;Birney E;Cunningham F;Harrow J;Herrero J;Hubbard TJ;Kinsella R;Muffato M;Parker A;Spudich G;Yates A;Zerbino DR;Searle SM
通讯作者：
Searle SM
影响因子：
64.8
作者：
Hughes, Jennifer F.;Skaletsky, Helen;Brown, Laura G.;Pyntikova, Tatyana;Graves, Tina;Fulton, Robert S.;Dugan, Shannon;Ding, Yan;Buhay, Christian J.;Kremitzki, Colin;Wang, Qiaoyan;Shen, Hua;Holder, Michael;Villasana, Donna;Nazareth, Lynne V.;Cree, Andrew;Courtney, Laura;Veizer, Joelle;Kotkiewicz, Holland;Cho, Ting-Jan;Koutseva, Natalia;Rozen, Steve;Muzny, Donna M.;Warren, Wesley C.;Gibbs, Richard A.;Wilson, Richard K.;Page, David C.
通讯作者：
Page, David C.
DOI：
10.1111/j.1469-185x.1931.tb01030.x
发表时间：
1931-10-01
影响因子：
--
作者：
Fisher, RA
通讯作者：
Fisher, RA
影响因子：
3.5
作者：
Dal Zotto, L;Quaderi, NA;Rugarli, EI
通讯作者：
Rugarli, EI
影响因子：
9.8
作者：
Froyen, Guy;Belet, Stefanie;Marynen, Peter
通讯作者：
Marynen, Peter