SOME EFFECTS OF CONTINUOUS LOW-DOSE CONGENITAL EXPOSURE TO METHYLMERCURY ON ORGAN GROWTH IN THE RAT FETUS
SOME EFFECTS OF CONTINUOUS LOW-DOSE CONGENITAL EXPOSURE TO METHYLMERCURY ON ORGAN GROWTH IN THE RAT FETUS
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DOI：
10.1002/tera.1420200107
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发表时间：
1979-01-01
期刊：
影响因子：
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通讯作者：
MOTTET, NK
中科院分区：
文献类型：
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作者：
CHEN, WJ;BODY, RL;MOTTET, NK
先天性低剂量暴露于甲基汞的大鼠胎儿产生了较小的后代，但没有解剖异常。本研究探讨了胎儿较小的机制。妊娠大鼠从妊娠第1天至妊娠第20天连续给予甲基汞水（25 ppm）。胎儿体重与母亲和胎儿的汞负荷呈负相关。实验中肝脏和肾脏的全器官DNA和蛋白质含量显着低于对照（P < 0.05），表明汞暴露胎儿的每个器官的细胞较少。当以每克组织为基础比较数据时，没有显着差异，表明每种细胞的数量和大小都没有减少。实验组中 3 H-胸苷掺入胎儿组织 DNA 的量也显着降低，表明增殖活性降低。我们从这项研究中得出的结论是，至少对于一些主要器官来说，汞暴露胎儿的尺寸减小是由于增殖活性降低而导致器官中的细胞减少。
Congenital low‐dose exposure of rat fetuses to methylmercury produced smaller offspring without anatomical abnormalities. The present study explored the mechanisms of the smallness of fetuses. The pregnant rats were given methylmercury water (25 ppm) from day 1 of pregnancy continuously until day 20 of gestation. There was a negative correlation of fetal weight and maternal and fetal mercury burden. The whole organ DNA and protein content of the livers and kidneys in the experiments were significantly lower than the control (P < 0.05) indicating that there were fewer cells per organ in the mercury exposed fetuses. When the data were compared on a per gram of tissue basis, there was no significant difference, indicating that the number and size of the cells of each were not diminished. The incorporation of3H‐thymidine into fetal tissue DNA was also substantially lower in the experimental group indicating decreased proliferative activity. We conclude from this study that, at least for some major organs, the decreased size in the mercury exposed fetuses is due to fewer cells in the organs due to decreased proliferative activity.