Protein-PCNA interactions: a DNA-scanning mechanism?
Protein-PCNA interactions: a DNA-scanning mechanism?
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DOI：
10.1016/s0968-0004(98)01223-7
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发表时间：
1998-07-01
影响因子：
13.8
通讯作者：
Hurwitz, J
中科院分区：
文献类型：
--
作者：
Kelman, Z;Hurwitz, J
增殖细胞核抗原在所有真核生物的核酸代谢中起着至关重要的作用。增殖细胞核抗原蛋白与大量蛋白质相互作用。这些蛋白质可以分为两类：第一类包含已知的酶活性蛋白质；第二类包含参与细胞周期进程、检查点控制和细胞分化的调节蛋白。有趣的是，所有已知的与增殖细胞核抗原相互作用的酶要么识别DNA上的特定结构，要么具有有限的DNA序列特异性。具有低序列特异性的蛋白质可以利用增殖细胞核抗原作为接头，以便与其DNA底物相互作用。
Proliferating-cell nuclear antigen (PCNA) plays an essential role in nucleic-acid metabolism in all eukaryotes. The PCNA protein interacts with a large number of proteins. These proteins can be divided into two groups: the first contains proteins that have a known enzymatic activity; the second contains regulatory proteins that are involved in cell-cycle progression, checkpoint control and cellular differentiation. Interestingly, all of the enzymes known to interact with PCNA either recognize specific structures on DNA or have limited DNA-sequence specificity. Proteins that have low sequence specificities could utilize PCNA as an adapter in order to interact with their DNA substrates.