Glycosomes: A comprehensive view of their metabolic roles in T-brucei
Glycosomes: A comprehensive view of their metabolic roles in T-brucei
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DOI：
10.1016/j.biocel.2017.01.015
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发表时间：
2017-04-01
影响因子：
4
通讯作者：
Bringaud, Frederic
中科院分区：
文献类型：
--
作者：
Allmann, Stefan;Bringaud, Frederic
过氧化物酶体是一种单膜细胞器，存在于从人类到酵母的大多数真核细胞和生物体中，在脂质代谢、自由基解毒、分化、发育、形态发生等方面发挥重要的代谢功能。有趣的是，原生动物寄生虫锥虫属（Trypanosoma）含有称为糖体的过氧化物酶体样细胞器，其缺乏标志性的过氧化物酶体途径和酶，如过氧化氢酶。糖体是唯一的过氧化物酶体样细胞器，含有糖酵解途径的大多数酶步骤以及嘧啶生物合成、嘌呤补救和核苷酸糖生物合成的酶。我们目前在这里的糖体代谢特点的概述，连同目前的观点，这种独特的代谢过氧化物酶体螯合的存在理由。(C)2017爱思唯尔有限公司版权所有
Peroxisomes are single-membrane cellular organelles, present in most eukaryotic cells and organisms from human to yeast, fulfilling essential metabolic functions in lipid metabolism, free radical detoxification, differentiation, development, morphogenesis, etc. Interestingly, the protozoan parasite species Trypanosoma contains peroxisome-like organelles named glycosomes, which lack hallmark peroxisomal pathways and enzymes, such as catalase. Glycosomes are the only peroxisome-like organelles containing most enzymatic steps of the glycolytic pathway as well as enzymes of pyrimidine biosynthesis, purine salvage and biosynthesis of nucleotide sugars. We-present here an overview of the glycosomal metabolic peculiarities together with the current view of the raison d'etre of this unique metabolic peroxisomal sequestration. (C) 2017 Elsevier Ltd. All rights reserved.