INFLUENCE OF LACTOSE ON FECAL MICROFLORA IN LACTOSE MALDIGESTORS
INFLUENCE OF LACTOSE ON FECAL MICROFLORA IN LACTOSE MALDIGESTORS
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DOI：
10.3109/08910609309141564
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发表时间：
1993-03-01
影响因子：
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通讯作者：
KIMURA, M
中科院分区：
文献类型：
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作者：
ITO, M;KIMURA, M
在24名日本男性志愿者中研究了乳糖摄入量对人体粪便微生物菌群和粪便有机酸的影响，这些志愿者每天服用15 g试验糖，持续6 d。24名受试者中有22名（92%）通过氢呼吸试验被归类为乳糖代谢障碍者。总粪便细菌的数量，特别是类杆菌和产气荚膜梭菌的数量减少，而乳酸杆菌，肠球菌，念珠菌属的数量。葡萄球菌在乳糖摄入后增加。乳糖的摄入没有显着改变粪便短链脂肪酸，但增加了甲酸和戊酸的浓度。这些结果表明，在被证实患有乳糖消化不良的受试者中，部分乳糖进入结肠，引起结肠微生物区系组成的变化。
The effects of lactose intake on the human faecal microflora and on the faecal organic acids were investigated in 24 Japanese male volunteers who took 15 g of the test sugar daily for 6 d. Twenty-two of the 24 subjects (92 per cent) were classified as lactose maldigestors by the hydrogen breath test. The numbers of total faecal bacteria, and specifically of bacteroides and Clostridium perfringens decreased while the numbers of lactobacilli, enterococci, Candida spp. and staphylococci increased after lactose consumption. The ingestion of lactose did not markedly alter faecal short chain fatty acids but increased the concentration of formic acid and valeric acid. These results suggest that in subjects with verified lactose maldigestion, part of the lactose passes into the colon, inducing changes in the colonic microflora composition.