Depression in men receiving androgen deprivation therapy for prostate cancer: A pilot study
Depression in men receiving androgen deprivation therapy for prostate cancer: A pilot study
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DOI：
10.1002/pon.592
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发表时间：
2002-11-01
期刊：
影响因子：
3.6
通讯作者：
Smith, MR
中科院分区：
文献类型：
--
作者：
Pirl, WF;Siegel, GI;Smith, MR
目的：前列腺癌是男性最常见的恶性肿瘤，也是全球男性癌症死亡的主要原因之一。前列腺癌的治疗通常包括雄激素剥夺疗法(ADT)。在ADT期间出现抑郁症状的报道正在涌现。这项研究调查了这一人群中与重度抑郁症相关的患病率和危险因素。方法：在麻省理工学院癌症中心接受ADT治疗的45名前列腺癌患者接受了DSM-IV和Beck抑郁问卷调查。结果：在接受ADT治疗的前列腺癌患者中，12.8%的人患有严重抑郁障碍，是全国男性抑郁症患病率的8倍，是65岁以上男性抑郁症患病率的32倍。重度抑郁与病情恶化、对ADT的药物反应、接受化疗或ADT的类型无关。在这个人群中，过去的抑郁症史与现在的抑郁症相关(p<；0.000)。在本样本中，服用ADT的患者中没有出现首发抑郁症病例。结论：这一数据表明接受ADT治疗的前列腺癌患者有显著的抑郁发生率，有抑郁病史的患者在接受该治疗时抑郁复发的风险可能特别大。版权所有(C)2002 John Wiley Sons，Ltd.
Purpose: Prostate cancer is the most common malignancy in men and one of the leading causes of cancer death in men internationally. Treatment for prostate cancer frequently includes androgen deprivation therapy (ADT). Reports of depressive symptoms arising during ADT are emerging. This study examines the prevalence rates and risk factors associated with major depression in this population. Method: 45 men with prostate cancer receiving ADT at the MGH Cancer Center were surveyed for depression with the SCID for Axis I disorders for DSM-IV and the Beck Depression Inventory. Results: Major depressive disorder was prevalent in 12.8% of the men with prostate cancer receiving ADT, eight times the national rate of depression in men, 32 times the rate in men over 65 years old. Major depression was not associated with worsening disease, medical response to ADT, receiving chemotherapy, or the type of ADT. Past history of depression was associated with current depression in this population (p < 0.000). No first onset cases of depression occurred on ADT in this sample. Conclusion: This data suggests a significant rate of major depression in men with prostate cancer receiving ADT and that men with past histories of depression may be at particular risk for recurrence of their depression while undergoing this treatment. Copyright (C) 2002 John Wiley Sons, Ltd.