Induction of oxidative stress and disintegrin metalloproteinase in human heart end-stage failure
Induction of oxidative stress and disintegrin metalloproteinase in human heart end-stage failure
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DOI：
10.1152/ajplung.00001.2002
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发表时间：
2002-08-01
影响因子：
4.9
通讯作者：
Tyagi, SC
中科院分区：
文献类型：
--
作者：
Hunt, MJ;Aru, GM;Tyagi, SC
Collagen degradation is required for the creation of new integrin binding sites necessary for cell survival. However, a complete separation between the matrix and the cell leads to apoptosis, dilatation, and failure. Previous studies have demonstrated increased metalloproteinase activity in the failing myocardium. To test the hypothesis that disintegrin metalloproteinase (DMP) is induced in human heart end-stage failure, left ventricle tissue from ischemic cardiomyopathic (ICM, n=10) and dilated cardiomyopathic (DCM, n=10) human hearts were obtained at the time of orthotopic cardiac transplant. Normal (n=5) tissue specimens were obtained from unused hearts. The levels of reduced oxygen species (ROS) were 12+/-2, 25+/-3, and 16+/-2 nmol (means+/-SE, P
