Peripheral blood neutrophil-to-lymphocyte ratio in inflammatory bowel disease and disease activity: A meta-analysis
Peripheral blood neutrophil-to-lymphocyte ratio in inflammatory bowel disease and disease activity: A meta-analysis
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DOI：
10.1016/j.intimp.2021.108235
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发表时间：
2021-10-19
影响因子：
5.6
通讯作者：
Wang, Qin
中科院分区：
文献类型：
--
作者：
Fu, Wei;Fu, Hu;Wang, Qin
目的：外周血中性粒细胞与淋巴细胞比值（NLR）是炎症性肠病（IBD）临床疾病活动性的一个有价值的预测指标。因此，我们通过荟萃分析来评估IBD患者外周血NLR的临床意义。方法：检索PubMed、Embase、Web of Science、Cochrane Library及中文数据库，检索时间为成立至2021年5月10日。我们使用95%置信区间（CI）的标准平均差（SMD）来估计合并效应，并使用亚组分析来研究异质性。结果：共纳入16项研究，包括2185名IBD患者和993名健康对照（hc）。1092例IBD患者外周血NLR值显著高于933例hcc患者（SMD = 1.54, 95% CI = 1.05-2.02, P < 0.001）， 1269例活动性IBD患者外周血NLR值显著高于1056例缓解性IBD患者（SMD = 1.55, 95% CI = 1.06-2.05, P < 0.001）。对IBD主要亚型的亚组分析显示，活动性溃疡性结肠炎（UC）患者外周血NLR值显著高于hcc (SMD = 2.04)，缓解性UC患者外周血NLR值显著高于hcc (SMD = 0.63)，活动性UC患者外周血NLR值显著高于缓解性UC患者（SMD = 1.32） （P < 0.05）。克罗恩病（CD）患者和活动期CD患者外周血NLR值均显著高于hc患者，SMD分别为0.52和3.53 （P < 0.001）。结论：外周血NLR可作为预测IBD患者疾病严重程度的有价值的生物标志物。
Objective: The peripheral blood neutrophil-to-lymphocyte ratio (NLR) is a valuable predictor of clinical disease activity in inflammatory bowel disease (IBD). Therefore, we conducted a meta-analysis to evaluate the clinical significance of peripheral blood NLR in IBD patients. Methods: A comprehensive literature search was conducted by searching PubMed, Embase, Web of Science, Cochrane Library, and Chinese databases from inception to May 10, 2021. We used the standard mean difference (SMD) with a 95% confidence interval (CI) to estimate the pooled effect and subgroup analysis to investigate heterogeneity. Results: Sixteen studies including 2185 IBD patients and 993 healthy controls (HCs) were enrolled in this study. The peripheral blood NLR values were significantly higher in 1,092 IBD patients than in 933 HCs (SMD = 1.54, 95% CI = 1.05-2.02, P < 0.001) and in 1,269 patients with active IBD than in 1,056 patients with remissive IBD (SMD = 1.55, 95% CI = 1.06-2.05, P < 0.001). Subgroup analysis of the major subtypes of IBD revealed significantly elevated peripheral blood NLR values in patients with active ulcerative colitis (UC) compared to HCs (SMD = 2.04), remissive UC than HCs (SMD = 0.63), and active UC than in those with remissive UC (SMD = 1.32) (P < 0.05). Both Crohn's disease (CD) patients and active CD patients had significantly elevated peripheral blood NLR values than HCs with the SMD of 0.52 and 3.53 (P < 0.001). Conclusions: Peripheral blood NLR could serve as a valuable biomarker for predicting disease severity in IBD patients.